V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) Antibody (HRP)
169€ (20 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) Antibody (HRP)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx316697
Tested Applications
ELISA
Description
VSIG4 Antibody (HRP) is a Rabbit Polyclonal against VSIG4 conjugated to HRP.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) Immunogen: Recombinant Human V-set and immunoglobulin domain-containing protein 4 protein (20-283 AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y279 |
| Gene ID | 11326 |
| NCBI Accession | NP_001093901.1 |
| OMIM | 300353 |
| Alias | CRIg,Z39IG,Protein Z39Ig |
| Background | Antibody anti-VSIG4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
V-set and immunoglobulin domain containing 4 (VSIG4) is a complement receptor and immune checkpoint protein that primarily functions as an inhibitory molecule in macrophages and antigen-presenting cells. As a negative regulator of T-cell activation, VSIG4 suppresses immune responses by binding to complement components, thereby reducing inflammation and preventing tissue damage in autoimmune and inflammatory conditions. Its immune-inhibitory properties make VSIG4 a potential target for immune modulation therapies, particularly in autoimmune diseases and cancer immunotherapy. In the tumor microenvironment, VSIG4 expression on macrophages is associated with immune evasion, as it inhibits T-cell-mediated anti-tumor responses. Elevated VSIG4 levels have been linked to poor prognosis in several cancers, including hepatocellular carcinoma and melanoma. Beyond its role in immunity, VSIG4 is implicated in metabolic processes, as it interacts with lipid metabolism pathways in macrophages, influencing foam cell formation in atherosclerosis. Therapeutic strategies targeting VSIG4 are being explored to enhance anti-tumor immunity or regulate excessive inflammation, highlighting its significance as a multifunctional immune regulatory molecule.
Productos relacionados
V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) Antibody
This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of …
Ver producto V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) Antibody
Rabbit Polyclonal against the VSIG4 protein.…
Ver producto
V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) Antibody
V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) Antibody is a Rabbit Polyclonal antibody for the detection …
Ver producto