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Telomerase Reverse Transcriptase (TERT) is a catalytic subunit of the enzyme telomerase, which is critical for maintaining telomere length and genomic stability. TERT is encoded by the TERT gene located on chromosome 5p15.33. Telomeres are repetitive nucleotide sequences (TTAGGG in humans) at the ends of chromosomes that protect them from degradation and fusion with neighboring chromosomes. TERT, in conjunction with the RNA component of telomerase (TERC), synthesizes telomeric DNA repeats onto chromosome ends. This activity counteracts the progressive shortening of telomeres that occurs during cell division. TERT is highly active in stem cells, germ cells, and cancer cells but is typically repressed in most somatic cells, leading to progressive telomere shortening and eventual cell senescence or apoptosis.
TERT is a large protein with several key structural domains:
TERT is classified as a reverse transcriptase enzyme. Although it does not have subtypes, its activity and regulation can vary significantly across different cell types and conditions, such as cancer versus normal somatic cells.
TERT serves several critical functions:
Abnormal TERT activity is associated with several clinical conditions:
Telomerase Reverse Transcriptase (TERT) is a crucial enzyme responsible for maintaining telomere length and ensuring genomic stability. It plays significant roles in cellular aging, stem cell function, and cancer. TERT activity is tightly regulated in somatic cells but reactivated in most cancers, making it a potential therapeutic target. Mutations and dysregulation of TERT are associated with various telomere syndromes and age-related diseases, highlighting its importance in human health and disease. Understanding TERT's mechanisms and regulation is vital for developing treatments for cancer and other telomere-related disorders.
Telomerase Reverse Transcriptase (TERT)
CMM9,DKCA2,DKCB4,EST2,PFBMFT1,TCS1,TP2,TRT hEST2,hTRT,Telomerase-associated protein 2
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con TERT - Telomerase Reverse Transcriptase
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 43 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | TERT | abx519511 | Cow Telomerase Reverse Transcriptase (TERT) ELISA Kit | Cow | Tissue homogenates,Cell lysates,Other biological fluids | 0.312 ng/ml - 20 ng/ml | 687.5 | 96 tests | Q27ID4 | RUO | ||
Abbexa | TERT | abx519512 | Dog Telomerase Reverse Transcriptase (TERT) ELISA Kit | Dog | Tissue homogenates,Cell lysates,Other biological fluids | 78 pg/ml - 5000 pg/ml | 687.5 | 96 tests | Q6A548 | RUO | ||
FineTest | TERT | EH2120 | Human TERT(Telomerase reverse transcriptase) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | O14746 | RUO | ||
Abbexa | TERT | abx153255 | Human Telomerase Reverse Transcriptase (TERT) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 6.0 pg/ml | 687.5 | 96 tests | RUO | |
Abbexa | TERT | abx251454 | Human Telomerase Reverse Transcriptase (TERT) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 556.25 | 96 tests | O14746 | RUO |
Abbexa | TERT | abx493564 | Human Telomerase Reverse Transcriptase (TERT) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 15.62 pg/ml - 1000 pg/ml | < 5.9 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | TERT | abx195441 | Human Telomerase Reverse Transcriptase (TERT) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 618.75 | 96 tests | RUO | |
FineTest | TERT | EM0730 | Mouse Tert(Telomerase reverse transcriptase) ELISA Kit | mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.313-20ng/ml | 96T | O70372 | RUO | ||
Abbexa | TERT | abx257661 | Mouse Telomerase (TERT) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 6.25 ng/ml - 400 ng/ml | 3.75 ng/ml | 562.5 | 96 tests | O70372 | RUO |
Abbexa | TERT | abx255078 | Mouse Telomerase Reverse Transcriptase (TERT) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | 537.5 | 96 tests | O70372 | RUO | |
FineTest | TERT | ER2133 | Rat TERT(Telomerase reverse transcriptase) ELISA Kit | rat | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | Q673L6 | RUO | ||
Abbexa | TERT | abx156136 | Rat Telomerase Reverse Transcriptase (TERT) ELISA Kit | Rat | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | < 11.7 pg/ml | 687.5 | 96 tests | RUO | |
Abbexa | TERT | abx256038 | Rat Telomerase (TERT) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | 46.9 pg/ml | 531.25 | 96 tests | Q673L6 | RUO |
Abbexa | TERT | abx493565 | Rat Telomerase Reverse Transcriptase (TERT) CLIA Kit | Rat | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 31.2 pg/ml - 2000 pg/ml | < 13.7 pg/ml | 812.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | TERT | abx300609 | Telomerase Reverse Transcriptase (TERT) Antibody | Dog | Polyclonal | Rabbit | Telomerase Reverse Transcriptase (TERT) | Unconjugated | ELISA | 162.5 | 20 µg | Q6A548 | RUO | |
Abbexa | TERT | abx103374 | Telomerase Reverse Transcriptase (TERT) Antibody | Human | Polyclonal | Rabbit | Telomerase Reverse Transcriptase (TERT) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | O14746 | RUO | |
Abbexa | TERT | abx016155 | Telomerase Reverse Transcriptase (TERT) Antibody | Human | Monoclonal | Mouse | Telomerase Reverse Transcriptase (TERT) | Unconjugated | ELISA, IHC, FCM | 362.5 | 100 µl | O14746 | RUO | |
Abbexa | TERT | abx211412 | Telomerase Reverse Transcriptase (TERT) Antibody | Human | Polyclonal | Rabbit | Telomerase Reverse Transcriptase (TERT) | Unconjugated | ELISA, IHC | 250 | 50 µl | O14746 | RUO | |
Abbexa | TERT | abx105964 | Telomerase Reverse Transcriptase (TERT) Antibody (Biotin) | Human | Polyclonal | Rabbit | Telomerase Reverse Transcriptase (TERT) | Biotin | ELISA | 162.5 | 20 µg | O14746 | RUO | |
Abbexa | TERT | abx032025 | TERT (pS1125) Antibody | Human | Polyclonal | Rabbit | TERT (pS1125) | Unconjugated | ELISA, DB | 281.25 | 80 µl | O14746 | RUO | |
Abbexa | TERT | abx323591 | Telomerase Reverse Transcriptase (TERT) Antibody | Human | Polyclonal | Rabbit | Telomerase Reverse Transcriptase (TERT) | Unconjugated | ELISA, WB | 187.5 | 50 µg | O14746 | RUO | |
Abbexa | TERT | abx110254 | Telomerase Reverse Transcriptase (TERT) Antibody | Human | Polyclonal | Rabbit | Telomerase Reverse Transcriptase (TERT) | Unconjugated | ELISA, IHC | 162.5 | 20 µg | O14746 | RUO | |
Abbexa | TERT | abx211395 | Telomerase Reverse Transcriptase (TERT) Antibody | Human | Polyclonal | Rabbit | Telomerase Reverse Transcriptase (TERT) | Unconjugated | ELISA, WB | 250 | 50 µl | O14746 | RUO | |
Abbexa | TERT | abx174734 | Telomerase Reverse Transcriptase (TERT) Antibody | Human | Monoclonal | Mouse | Telomerase Reverse Transcriptase (TERT) | Unconjugated | WB, IHC, IF/ICC | 787.5 | 1 ml | RUO | ||
Abbexa | TERT | abx433353 | Telomerase Reverse Transcriptase (TERT) Antibody | Human | Polyclonal | Goat | Telomerase Reverse Transcriptase (TERT) | Unconjugated | P-ELISA, WB, IF/ICC, FCM | 387.5 | 200 µl | RUO | ||
Abbexa | TERT | abx107379 | Telomerase Reverse Transcriptase (TERT) Antibody (FITC) | Human | Polyclonal | Rabbit | Telomerase Reverse Transcriptase (TERT) | FITC | 162.5 | 20 µg | O14746 | RUO | ||
Abbexa | TERT | abx108799 | Telomerase Reverse Transcriptase (TERT) Antibody (HRP) | Human | Polyclonal | Rabbit | Telomerase Reverse Transcriptase (TERT) | HRP | ELISA | 162.5 | 20 µg | O14746 | RUO | |
Abbexa | TERT | abx402409 | Telomerase Reverse Transcriptase (TERT) Antibody | Human | Monoclonal | Rabbit | Telomerase Reverse Transcriptase (TERT) | Unconjugated | ELISA, IHC | 287.5 | 50 µl | O14746 | RUO | |
Abbexa | TERT | abx324977 | Telomerase Reverse Transcriptase (TERT) Antibody | Human | Polyclonal | Rabbit | Telomerase Reverse Transcriptase (TERT) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | O14746 | RUO | |
Abbexa | TERT | abx027803 | Telomerase Reverse Transcriptase (TERT) Antibody | Human | Polyclonal | Rabbit | Telomerase Reverse Transcriptase (TERT) | Unconjugated | ELISA, WB, IHC, IF/ICC, FCM | 281.25 | 80 µl | O14746 | RUO | |
Abbexa | TERT | abx027802 | Telomerase Reverse Transcriptase (TERT) Antibody | Human | Polyclonal | Rabbit | Telomerase Reverse Transcriptase (TERT) | Unconjugated | ELISA, WB, IF/ICC, FCM | 281.25 | 80 µl | O14746 | RUO | |
Abbexa | TERT | abx211411 | Telomerase Reverse Transcriptase (TERT) Antibody | Human | Polyclonal | Rabbit | Telomerase Reverse Transcriptase (TERT) | Unconjugated | ELISA, IHC | 250 | 50 µl | O14746 | RUO | |
Abbexa | TERT | abx339525 | Telomerase Reverse Transcriptase (TERT) Antibody | Human | Polyclonal | Rabbit | Telomerase Reverse Transcriptase (TERT) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | O14746 | RUO | |
Abbexa | TERT | abx324319 | Telomerase Reverse Transcriptase (TERT) Antibody | Human | Polyclonal | Rabbit | Telomerase Reverse Transcriptase (TERT) | Unconjugated | ELISA, WB, IF/ICC | 187.5 | 50 µg | O14746 | RUO | |
Abbexa | TERT | abx324395 | Telomerase Reverse Transcriptase Phospho-Ser824 (TERT pS824) Antibody | Human | Polyclonal | Rabbit | Telomerase Reverse Transcriptase Phospho-Ser824 (TERT pS824) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | O14746 | RUO | |
Abbexa | TERT | abx224167 | Telomerase Reverse Transcriptase (TERT) Antibody | Human | Monoclonal | Mouse | Telomerase Reverse Transcriptase (TERT) | ELISA, IHC, FCM | 362.5 | 100 µl | O14746 | RUO | ||
Abbexa | TERT | abx002167 | Telomerase Reverse Transcriptase (TERT) Antibody | Human | Polyclonal | Rabbit | Telomerase Reverse Transcriptase (TERT) | Unconjugated | WB | 175 | 20 µl | O14746 | RUO | |
Abbexa | TERT | abx103375 | Telomerase Reverse Transcriptase (TERT) Antibody | Mouse | Polyclonal | Rabbit | Telomerase Reverse Transcriptase (TERT) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | TERT | abx174735 | Telomerase Reverse Transcriptase (TERT) Antibody | Rat | Monoclonal | Mouse | Telomerase Reverse Transcriptase (TERT) | Unconjugated | WB, IHC, IF/ICC | 850 | 1 ml | RUO | ||
Abbexa | TERT | abx103376 | Telomerase Reverse Transcriptase (TERT) Antibody | Rat | Polyclonal | Rabbit | Telomerase Reverse Transcriptase (TERT) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | Q673L6 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | TERT | abx069253 | Rat Telomerase Reverse Transcriptase (TERT) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | Q673L6 | RUO |
Abbexa | TERT | abx069252 | Mouse Telomerase Reverse Transcriptase (TERT) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | O70372 | RUO |
Abbexa | TERT | abx069251 | Human Telomerase Reverse Transcriptase (TERT) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | O14746 | RUO |
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