TERT (pS1125) Antibody
Pida mas información
935106861
info@markelab.com
Precio
292.5€ (80 µl)
Antibody anti-TERT
proveedor
Abbexareference
abx032025Tested Applications
ELISA, DBreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.
Background
Telomerase Reverse Transcriptase (TERT) is the catalytic subunit of the telomerase enzyme complex, responsible for maintaining telomere length by adding telomeric repeats to chromosome ends. TERT is crucial for cellular longevity, stem cell renewal, and genomic stability. It is highly active in embryonic and stem cells but repressed in most somatic cells. Reactivation of TERT is a hallmark of cancer, providing cells with replicative immortality. Beyond telomere maintenance, TERT has non-telomeric roles in transcriptional regulation, mitochondrial function, and resistance to apoptosis. Its misregulation is implicated in aging, cancer, and telomere-related diseases such as dyskeratosis congenita.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
TERT (pS1125)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, DB
purification
Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
recommended dilution
DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
TERT
dry ice
No
availability
Shipped within 5-10 working days.
alias
CMM9,DKCA2,DKCB4,EST2,PFBMFT1,TCS1,TP2,TRT hEST2,hTRT,Telomerase-associated protein 2
uniprot id
NCBI accession
NP_001180305.1, NM_001193376.1
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