Telomerase Reverse Transcriptase (TERT) Antibody

Background

Telomerase Reverse Transcriptase (TERT) is the catalytic subunit of the telomerase enzyme complex, responsible for maintaining telomere length by adding telomeric repeats to chromosome ends. TERT is crucial for cellular longevity, stem cell renewal, and genomic stability. It is highly active in embryonic and stem cells but repressed in most somatic cells. Reactivation of TERT is a hallmark of cancer, providing cells with replicative immortality. Beyond telomere maintenance, TERT has non-telomeric roles in transcriptional regulation, mitochondrial function, and resistance to apoptosis. Its misregulation is implicated in aging, cancer, and telomere-related diseases such as dyskeratosis congenita.