Family main features
Neuropeptide FF Receptors (NPFFR), also known as NPFF receptors or GPR147, are G protein-coupled receptors (GPCRs) that bind to neuropeptide FF (NPFF) and related peptides. NPFFR is widely expressed in the central nervous system and peripheral tissues and plays a role in modulating various physiological processes, including pain modulation, stress responses, cardiovascular function, and reproductive behavior.The primary ligands for Neuropeptide FF receptors are neuropeptide FF (NPFF) and related peptides, including NPFF, neuropeptide AF (NPAF), and neuropeptide SF (NPSF). These peptides bind to NPFF receptors and activate intracellular signaling pathways, leading to various physiological responses.
NPFF receptors, like other GPCRs, possess seven transmembrane domains, an extracellular N-terminus, and an intracellular C-terminus. They also contain binding sites for G proteins, which initiate intracellular signaling upon receptor activation.
There are two known subtypes of Neuropeptide FF receptors: NPFFR1 and NPFFR2. These subtypes share significant sequence homology but exhibit differences in tissue distribution and signaling properties.
1. NPFFR1: Predominantly expressed in the central nervous system, including regions involved in pain processing, stress responses, and cardiovascular regulation.
2. NPFFR2: Expressed in both the central nervous system and peripheral tissues, including the gastrointestinal tract, adipose tissue, and reproductive organs. It plays a role in regulating pain perception, stress responses, and reproductive behavior.
Neuropeptide FF receptors mediate a wide range of physiological functions, including:
Dysregulation of Neuropeptide FF receptor signaling has been implicated in various disorders and conditions, including chronic pain, stress-related disorders, cardiovascular diseases, and reproductive disorders. Alterations in NPFFR expression or function can disrupt normal physiological processes, contributing to disease pathogenesis.
Neuropeptide FF receptors have emerged as potential therapeutic targets for the treatment of chronic pain, stress-related disorders, cardiovascular diseases, and reproductive disorders. Modulating NPFFR signaling with agonists or antagonists could offer therapeutic benefits by regulating pain perception, stress responses, cardiovascular function, and reproductive behavior. Several pharmacological agents targeting NPFF receptors are currently under investigation in preclinical and clinical studies as potential therapeutics. Selective modulation of specific Neuropeptide FF receptor subtypes may help minimize side effects and maximize therapeutic efficacy.
Neuropeptide FF receptor 1 (NPFFR1)
NPFFR1,GPR147,NPFF1,NPFF1R1,OT7T022,G protein-coupled receptor 147,RFamide-related peptide receptor GnIH-R,GnIH-R/RFRP-3
Neuropeptide FF receptor 2 (NPFFR2)
NPFFR2,GPR74,HLWAR77,NPFF2,NPGPR,F8Famide receptor,GPR74 ,NPGPR,G protein-coupled receptor 74
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | NPFFR2 | EH1402 | Human NPFFR2(Neuropeptide FF receptor 2) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Competitive ELISA, Coated with Antigen | 0.625-40ng/ml | 96T | Q9Y5X5 | RUO | ||
Abbexa | NPFFR1 | abx535672 | Human Neuropeptide FF receptor 1 (NPFFR1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9GZQ6 | RUO | ||
Abbexa | NPFFR2 | abx250677 | Human Neuropeptide FF receptor 2 (NPFFR2) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.625 ng/ml - 40 ng/ml | 687.5 | 96 tests | Q9Y5X5 | RUO | |
Abbexa | NPFFR2 | abx515899 | Mouse Neuropeptide FF receptor 2 (NPFFR2) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | 39.31 pg/ml | 687.5 | 96 tests | Q924H0 | RUO |
Abbexa | NPFFR1 | abx535673 | Rat Neuropeptide FF Receptor 1 (NPFFR1) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9EP86 | RUO | ||
Abbexa | NPFFR2 | abx515900 | Rat Neuropeptide FF receptor 2 (NPFFR2) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.78 ng/ml - 50 ng/ml | 687.5 | 96 tests | Q9EQD2 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | NPFFR2 | FNab05815 | anti- NPFFR2 antibody | human | polyclonal | Rabbit | neuropeptide FF receptor 2 | IgG | Unconjugated | ELISA, IHC | 100µg | Q9Y5X5 | RUO | |
Abbexa | NPFFR1 | abx027869 | Neuropeptide FF Receptor 1 (NPFFR1) Antibody | Human | Polyclonal | Rabbit | Neuropeptide FF Receptor 1 (NPFFR1) | Unconjugated | ELISA, WB | 250 | 80 µl | Q9GZQ6 | RUO | |
Abbexa | NPFFR1 | abx433057 | Neuropeptide FF Receptor 1 (NPFFR1) Antibody | Human | Polyclonal | Goat | Neuropeptide FF Receptor 1 (NPFFR1) | Unconjugated | P-ELISA, WB | 387.5 | 200 µl | RUO | ||
Abbexa | NPFFR2 | abx235815 | Neuropeptide FF Receptor 2 (NPFFR2) Antibody | Human | Polyclonal | Rabbit | Neuropeptide FF Receptor 2 (NPFFR2) | Unconjugated | ELISA, IHC | 350 | 100 µg | Q9Y5X5 | RUO | |
Abbexa | NPFFR2 | abx343966 | Neuropeptide FF receptor 2 (NPFFR2) Antibody (Biotin) | Human | Polyclonal | Rabbit | Neuropeptide FF receptor 2 (NPFFR2) | Biotin | ELISA | 250 | 50 µl | Q9Y5X5 | RUO | |
Abbexa | NPFFR2 | abx027655 | Neuropeptide FF Receptor 2 (NPFFR2) Antibody | Human | Polyclonal | Rabbit | Neuropeptide FF Receptor 2 (NPFFR2) | Unconjugated | ELISA, WB | 281.25 | 80 µl | Q9Y5X5 | RUO | |
Abbexa | NPFFR2 | abx343965 | Neuropeptide FF receptor 2 (NPFFR2) Antibody (FITC) | Human | Polyclonal | Rabbit | Neuropeptide FF receptor 2 (NPFFR2) | FITC | 250 | 50 µl | Q9Y5X5 | RUO | ||
Abbexa | NPFFR2 | abx343963 | Neuropeptide FF receptor 2 (NPFFR2) Antibody | Human | Polyclonal | Rabbit | Neuropeptide FF receptor 2 (NPFFR2) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q9Y5X5 | RUO | |
Abbexa | NPFFR2 | abx343967 | Neuropeptide FF receptor 2 (NPFFR2) Antibody | Human | Polyclonal | Rabbit | Neuropeptide FF receptor 2 (NPFFR2) | Unconjugated | ELISA, IF/ICC | 250 | 50 µl | Q9Y5X5 | RUO | |
Abbexa | NPFFR2 | abx343970 | Neuropeptide FF receptor 2 (NPFFR2) Antibody (Biotin) | Human | Polyclonal | Rabbit | Neuropeptide FF receptor 2 (NPFFR2) | Biotin | ELISA | 250 | 50 µl | Q9Y5X5 | RUO | |
Abbexa | NPFFR2 | abx343968 | Neuropeptide FF receptor 2 (NPFFR2) Antibody (HRP) | Human | Polyclonal | Rabbit | Neuropeptide FF receptor 2 (NPFFR2) | HRP | ELISA | 250 | 50 µl | Q9Y5X5 | RUO | |
Abbexa | NPFFR2 | abx343964 | Neuropeptide FF receptor 2 (NPFFR2) Antibody (HRP) | Human | Polyclonal | Rabbit | Neuropeptide FF receptor 2 (NPFFR2) | HRP | ELISA | 250 | 50 µl | Q9Y5X5 | RUO | |
Abbexa | NPFFR2 | abx343969 | Neuropeptide FF receptor 2 (NPFFR2) Antibody (FITC) | Human | Polyclonal | Rabbit | Neuropeptide FF receptor 2 (NPFFR2) | FITC | 250 | 50 µl | Q9Y5X5 | RUO |
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