Neuropeptide FF Receptor 1 (NPFFR1) Antibody

Este producto es parte de NPFFR - Neuropeptide FF receptor
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416€ (200 µl)

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935106861
info@markelab.com
name
Neuropeptide FF Receptor 1 (NPFFR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx433057
tested applications
P-ELISA, WB

Description

NPFFR1 Antibody is a Goat Polyclonal antibody against NPFFR1.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Neuropeptide FF Receptor 1 (NPFFR1)
Host
Goat
Reactivity
Human
Recommended Dilution
P-ELISA: 1/64000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Size 1
200 µl
Form
Liquid
Tested Applications
P-ELISA, WB
Buffer
Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Gene ID
64106
NCBI Accession
NP_071429.1
Alias
NPFFR1,GPR147,NPFF1,NPFF1R1,OT7T022,G protein-coupled receptor 147,RFamide-related peptide receptor GnIH-R,GnIH-R/RFRP-3
Background
Antibody anti-NPFFR1
Status
RUO
Note
Concentration: 0.5 mg/ml - 

Descripción

NPFFR1, also known as GPR147, is a G protein-coupled receptor activated by neuropeptide FF (NPFF), a member of the RFamide peptide family. NPFFR1 is predominantly expressed in the central nervous system (CNS), particularly in regions involved in pain modulation, opioid signaling, and neuroendocrine regulation. Activation of NPFFR1 couples to Gi/o proteins, inhibiting adenylate cyclase and reducing cAMP levels, leading to the modulation of synaptic transmission and neuronal excitability. NPFFR1 plays a critical role in modulating opioid analgesia, acting as an anti-opioid receptor to counteract the effects of endogenous and exogenous opioids, including morphine tolerance and dependence. Additionally, NPFFR1 is involved in regulating stress responses, cardiovascular function, and neuroendocrine signaling. Dysregulation of NPFFR1 has been associated with chronic pain, opioid tolerance, and stress-related disorders. NPFFR1 antagonists are being investigated as potential therapies for enhancing opioid analgesia and reducing tolerance, while its broader roles in stress and cardiovascular regulation remain under exploration.

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