Rat Neuropeptide FF Receptor 1 (NPFFR1) ELISA Kit
715€ (96 tests)
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935106861
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name
Rat Neuropeptide FF Receptor 1 (NPFFR1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx535673
tested applications
ELISA
Description
Rat Neuropeptide FF Receptor 1 (NPFFR1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Neuropeptide FF receptor 1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Neuropeptide FF Receptor 1 (NPFFR1) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.12 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9EP86 |
| Alias | NPFFR1,GPR147,NPFF1,NPFF1R1,OT7T022,G protein-coupled receptor 147,RFamide-related peptide receptor GnIH-R,GnIH-R/RFRP-3 |
| Background | Elisa kits for NPFFR1 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
NPFFR1, also known as GPR147, is a G protein-coupled receptor activated by neuropeptide FF (NPFF), a member of the RFamide peptide family. NPFFR1 is predominantly expressed in the central nervous system (CNS), particularly in regions involved in pain modulation, opioid signaling, and neuroendocrine regulation. Activation of NPFFR1 couples to Gi/o proteins, inhibiting adenylate cyclase and reducing cAMP levels, leading to the modulation of synaptic transmission and neuronal excitability. NPFFR1 plays a critical role in modulating opioid analgesia, acting as an anti-opioid receptor to counteract the effects of endogenous and exogenous opioids, including morphine tolerance and dependence. Additionally, NPFFR1 is involved in regulating stress responses, cardiovascular function, and neuroendocrine signaling. Dysregulation of NPFFR1 has been associated with chronic pain, opioid tolerance, and stress-related disorders. NPFFR1 antagonists are being investigated as potential therapies for enhancing opioid analgesia and reducing tolerance, while its broader roles in stress and cardiovascular regulation remain under exploration.
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