Human Neuropeptide FF receptor 1 (NPFFR1) ELISA Kit

Este producto es parte de NPFFR - Neuropeptide FF receptor
Human Neuropeptide FF receptor 1 (NPFFR1) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for NPFFR1

proveedor

Abbexa

reference

abx535672

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Neuropeptide FF receptor 1 (NPFFR1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Neuropeptide FF receptor 1 (NPFFR1) concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

NPFFR1, also known as GPR147, is a G protein-coupled receptor activated by neuropeptide FF (NPFF), a member of the RFamide peptide family. NPFFR1 is predominantly expressed in the central nervous system (CNS), particularly in regions involved in pain modulation, opioid signaling, and neuroendocrine regulation. Activation of NPFFR1 couples to Gi/o proteins, inhibiting adenylate cyclase and reducing cAMP levels, leading to the modulation of synaptic transmission and neuronal excitability. NPFFR1 plays a critical role in modulating opioid analgesia, acting as an anti-opioid receptor to counteract the effects of endogenous and exogenous opioids, including morphine tolerance and dependence. Additionally, NPFFR1 is involved in regulating stress responses, cardiovascular function, and neuroendocrine signaling. Dysregulation of NPFFR1 has been associated with chronic pain, opioid tolerance, and stress-related disorders. NPFFR1 antagonists are being investigated as potential therapies for enhancing opioid analgesia and reducing tolerance, while its broader roles in stress and cardiovascular regulation remain under exploration.

Características del producto

category

ELISA Kits


immunogen target

Neuropeptide FF receptor 1 (NPFFR1)


reactivity

Human


test range

0.156 ng/ml - 10 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

NPFFR1,GPR147,NPFF1,NPFF1R1,OT7T022,G protein-coupled receptor 147,RFamide-related peptide receptor GnIH-R,GnIH-R/RFRP-3


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

NPFFR1


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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