Human Neuropeptide FF receptor 2 (NPFFR2) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for NPFFR2
proveedor
Abbexareference
abx250677Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Neuropeptide FF receptor 2 (NPFFR2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Neuropeptide FF receptor 2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
NPFFR2, also known as GPR74, is a G protein-coupled receptor that binds neuropeptide FF (NPFF) and related RFamide peptides. NPFFR2 is expressed in the central nervous system, particularly in the spinal cord, hypothalamus, and brainstem, as well as in peripheral tissues, where it modulates pain signaling, opioid responses, and energy homeostasis. NPFFR2 activation predominantly couples to Gi/o proteins, inhibiting adenylate cyclase activity and reducing cAMP levels, which influences neurotransmitter release and neuronal excitability. NPFFR2 is involved in nociceptive processing, functioning as an anti-opioid receptor to reduce the analgesic effects of opioids and contribute to opioid tolerance. Beyond pain regulation, NPFFR2 has been implicated in energy metabolism, feeding behavior, and stress responses. Dysregulation of NPFFR2 signaling is associated with chronic pain, opioid dependence, and metabolic disorders. Therapeutically, NPFFR2 modulation holds promise for improving opioid therapy by reducing tolerance and dependence while offering potential targets for metabolic and pain-related disorders.
Características del producto
category
ELISA Kits
immunogen target
Neuropeptide FF receptor 2 (NPFFR2)
reactivity
Human
test range
0.625 ng/ml - 40 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
NPFFR2,GPR74,HLWAR77,NPFF2,NPGPR,F8Famide receptor,GPR74 ,NPGPR,G protein-coupled receptor 74
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
NPFFR2
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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