Human NPFFR2 (Neuropeptide FF receptor 2) ELISA Kit
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935106861
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name
Human NPFFR2 (Neuropeptide FF receptor 2) ELISA Kit
category
ELISA Kits
provider
FineTest
reference
EH1402
tested applications
ELISA
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 2 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.625-40ng/ml |
| Sensitivity | 0.375ng/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | Q9Y5X5 |
| Alias | NPFFR2,GPR74,HLWAR77,NPFF2,NPGPR,F8Famide receptor,GPR74 ,NPGPR,G protein-coupled receptor 74 |
| Background | Elisa kits for NPFFR2 |
| Status | RUO |
NPFFR2, also known as GPR74, is a G protein-coupled receptor that binds neuropeptide FF (NPFF) and related RFamide peptides. NPFFR2 is expressed in the central nervous system, particularly in the spinal cord, hypothalamus, and brainstem, as well as in peripheral tissues, where it modulates pain signaling, opioid responses, and energy homeostasis. NPFFR2 activation predominantly couples to Gi/o proteins, inhibiting adenylate cyclase activity and reducing cAMP levels, which influences neurotransmitter release and neuronal excitability. NPFFR2 is involved in nociceptive processing, functioning as an anti-opioid receptor to reduce the analgesic effects of opioids and contribute to opioid tolerance. Beyond pain regulation, NPFFR2 has been implicated in energy metabolism, feeding behavior, and stress responses. Dysregulation of NPFFR2 signaling is associated with chronic pain, opioid dependence, and metabolic disorders. Therapeutically, NPFFR2 modulation holds promise for improving opioid therapy by reducing tolerance and dependence while offering potential targets for metabolic and pain-related disorders.
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