NPFFR2 antibody
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935106861
info@markelab.com
name
NPFFR2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab05815
tested applications
ELISA, IHC
Description
Receptor for NPAF(A-18-F-amide) and NPFF(F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | neuropeptide FF receptor 2 (NPFFR2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9Y5X5 |
| Gene ID | 10886 |
| Alias | NPFFR2,GPR74,HLWAR77,NPFF2,NPGPR,F8Famide receptor,GPR74 ,NPGPR,G protein-coupled receptor 74 |
| Background | Antibody anti-NPFFR2 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
NPFFR2, also known as GPR74, is a G protein-coupled receptor that binds neuropeptide FF (NPFF) and related RFamide peptides. NPFFR2 is expressed in the central nervous system, particularly in the spinal cord, hypothalamus, and brainstem, as well as in peripheral tissues, where it modulates pain signaling, opioid responses, and energy homeostasis. NPFFR2 activation predominantly couples to Gi/o proteins, inhibiting adenylate cyclase activity and reducing cAMP levels, which influences neurotransmitter release and neuronal excitability. NPFFR2 is involved in nociceptive processing, functioning as an anti-opioid receptor to reduce the analgesic effects of opioids and contribute to opioid tolerance. Beyond pain regulation, NPFFR2 has been implicated in energy metabolism, feeding behavior, and stress responses. Dysregulation of NPFFR2 signaling is associated with chronic pain, opioid dependence, and metabolic disorders. Therapeutically, NPFFR2 modulation holds promise for improving opioid therapy by reducing tolerance and dependence while offering potential targets for metabolic and pain-related disorders.
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