Family main features
Myomesin (MYOM) is a key structural protein found in the M-band of the sarcomere, the fundamental unit of muscle contraction in striated muscle cells. It plays a critical role in maintaining the structural integrity and alignment of the thick filaments within the sarcomere, ensuring efficient muscle contraction and force transmission. Myomesin is part of the myosin superfamily and is highly conserved across various species, underscoring its essential function in muscle physiology.
The MYOM gene family includes several isoforms, such as MYOM1, MYOM2, and MYOM3, each with specific expression patterns and functions in different muscle types. The expression of myomesin is tightly regulated during muscle development and in response to physiological demands, reflecting its importance in muscle maintenance and adaptation.
Myomesin is a large, modular protein characterized by a series of immunoglobulin (Ig)-like and fibronectin type III (FNIII) domains. The general structure includes:
The multi-domain architecture of myomesin allows it to act as a molecular scaffold, maintaining the precise alignment and spacing of the thick filaments within the sarcomere. The flexibility conferred by the Ig-like and FNIII domains is vital for the protein's ability to withstand the mechanical stresses experienced during muscle contraction and relaxation cycles.
Myomesin is classified into three main isoforms:
Each isoform exhibits distinct expression patterns and functional specializations, reflecting the diverse mechanical demands placed on different muscle types.
Myomesin serves several critical functions in muscle cells:
The integrity and functionality of myomesin are crucial for maintaining muscle performance and adaptability, particularly under conditions of high mechanical load or injury.
Mutations or alterations in myomesin expression and function are associated with several muscle-related disorders:
Research into myomesin-related pathologies aims to understand the molecular mechanisms underlying these conditions and to develop potential therapeutic strategies.
Myomesin is a critical structural protein in the M-band of the sarcomere, playing a vital role in maintaining the integrity and functionality of striated muscles. Its modular structure, composed of Ig-like and FNIII domains, allows it to provide structural support, elasticity, and flexibility to muscle cells. Myomesin exists in several isoforms, each with specific roles in different muscle types. Dysregulation or mutation of myomesin can lead to various muscle disorders, highlighting its importance in muscle physiology and pathology. Understanding the detailed functions and interactions of myomesin is essential for developing targeted treatments for muscle-related diseases.
myomesin 1 (MYOM1)
SKELEMIN,Myomesin family member 1,190 kDa titin-associated protein,190 kDa connectin-associated protein
myomesin 2 (MYOM2)
TTNAP,Myomesin family member 2,M-protein,165 kDa connectin-associated protein,165 kDa titin-associated protein
myomesin 3 (MYOM3)
Myomesin family member 3
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (ELISA Kits, Primary Antibodies, Proteins and Peptides, CLIA Kits) relacionados con MYOM - myomesin
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 20 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | MYOM3 | EH1511 | Human MYOM3(Myomesin-3) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | Q5VTT5 | RUO | ||
Abbexa | MYOM1 | abx534279 | Human Myomesin-1 (MYOM1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | P52179 | RUO | ||
Abbexa | MYOM2 | abx152438 | Human Myomesin 2 (MYOM2) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.12 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | MYOM2 | abx495483 | Human Myomesin 2 (MYOM2) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.123 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | MYOM3 | abx250795 | Human Myomesin 3 (MYOM3) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q5VTT5 | RUO | |
Abbexa | MYOM1 | abx534280 | Mouse Myomesin-1 (MYOM1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q62234 | RUO | ||
Abbexa | MYOM3 | abx516471 | Mouse Myomesin 3 (MYOM3) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | 687.5 | 96 tests | A2ABU4 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | MYOM1 | FNab05516 | anti- MYOM1-Specific antibody | human | polyclonal | Rabbit | myomesin 1, 185kDa | IgG | Unconjugated | ELISA, WB, IHC | 100µg | P52179 | RUO | |
FineTest | MYOM3 | FNab05517 | anti- MYOM3 antibody | human | polyclonal | Rabbit | myomesin family, member 3 | IgG | Unconjugated | ELISA, WB, IP | 100µg | Q5VTT5 | RUO | |
Abbexa | MYOM1 | abx014612 | Myomesin 1 (MYOM1) Antibody | Human | Polyclonal | Rabbit | Myomesin 1 (MYOM1) | Unconjugated | IHC | 43.75 | 10 µg | P52179 | RUO | |
Abbexa | MYOM1 | abx323025 | Myomesin 1 (MYOM1) Antibody | Human | Polyclonal | Rabbit | Myomesin 1 (MYOM1) | Unconjugated | ELISA, IHC | 187.5 | 50 µg | P52179 | RUO | |
Abbexa | MYOM1 | abx235516 | MYOM1-Specific Antibody | Human | Polyclonal | Rabbit | MYOM1-Specific | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | P52179 | RUO | |
Abbexa | MYOM1 | abx113927 | Myomesin 1 (MYOM1) Antibody | Human | Polyclonal | Rabbit | Myomesin 1 (MYOM1) | Unconjugated | ELISA, WB, IHC, IF/ICC | 612.5 | 100 µl | P52179 | RUO | |
Abbexa | MYOM2 | abx131661 | Myomesin 2 (MYOM2) Antibody | Human | Polyclonal | Rabbit | Myomesin 2 (MYOM2) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | P54296 | RUO | |
Abbexa | MYOM2 | abx173670 | Myomesin 2 (MYOM2) Antibody | Human | Monoclonal | Mouse | Myomesin 2 (MYOM2) | Unconjugated | WB, IHC, IF/ICC | 787.5 | 1 ml | RUO | ||
Abbexa | MYOM2 | abx014613 | Myomesin 2 (MYOM2) Antibody | Human | Polyclonal | Rabbit | Myomesin 2 (MYOM2) | Unconjugated | ELISA, WB | 43.75 | 10 µg | P54296 | RUO | |
Abbexa | MYOM2 | abx326279 | Myomesin 2 (MYOM2) Antibody | Human | Polyclonal | Rabbit | Myomesin 2 (MYOM2) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P54296 | RUO | |
Abbexa | MYOM3 | abx235517 | Myomesin 3 (MYOM3) Antibody | Human | Polyclonal | Rabbit | Myomesin 3 (MYOM3) | Unconjugated | ELISA, WB, IP | 350 | 100 µg | Q5VTT5 | RUO | |
Abbexa | MYOM3 | abx113928 | Myomesin 3 (MYOM3) Antibody | Human | Polyclonal | Rabbit | Myomesin 3 (MYOM3) | Unconjugated | ELISA, WB | 612.5 | 100 µl | Q5VTT5 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | MYOM2 | abx650739 | Human Myomesin 2 (MYOM2) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | P54296 | RUO |
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