Family main features
Myeloid differentiation primary response 88 (MYD88) is a key adaptor protein involved in the signaling pathways of the innate immune system. It plays a crucial role in the activation of inflammatory responses by mediating signals from toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). Upon activation by pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs), MYD88 recruits downstream signaling molecules, leading to the activation of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs), which promote the expression of pro-inflammatory cytokines. This process is essential for the host defense against infections and the regulation of immune responses.
MYD88 is composed of several functional domains:
MYD88 is a unique and essential adaptor protein in the TLR/IL-1R signaling pathways, with no direct subtypes. However, it interacts with various other signaling molecules, such as:
MYD88 is integral to multiple immune functions:
Dysregulation or mutations in MYD88 can lead to various diseases:
Myeloid differentiation primary response 88 (MYD88) is a critical adaptor protein in the TLR/IL-1R signaling pathways, essential for innate immune responses and inflammation. Structurally, MYD88 comprises a death domain for protein-protein interactions, an intermediate domain, and a TIR domain for receptor binding. MYD88 mediates the activation of NF-κB and MAPKs, leading to the production of pro-inflammatory cytokines. Dysregulation of MYD88 is associated with immunodeficiencies, autoimmune diseases, cancer, and chronic inflammatory conditions. Understanding the role and mechanisms of MYD88 in immune signaling is vital for developing therapeutic interventions for these diseases.
Myeloid differentiation primary response 88 (MYD88)
MYD88D,Myeloid differentiation primary response 88, IMD68
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | MYD88 | abx355683 | Chicken Myeloid Differentiation Primary Response Protein MyD88 (MYD88) ELISA Kit | Chicken | Serum,Plasma,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 662.5 | 96 tests | RUO | |
Abbexa | MYD88 | abx518196 | Cow Myeloid Differentiation Primary Response Protein MyD88 (MYD88) ELISA Kit | Cow | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q599T9 | RUO | ||
FineTest | MYD88 | EH0240 | Human MYD88(Myeloid differentiation primary response protein MyD88) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | Q99836 | RUO | ||
Abbexa | MYD88 | abx570253 | Low Sample Volume Human Myeloid Differentiation Primary Response Protein MyD88 (MYD88) ELISA Kit | Human | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 5.7 pg/ml | 743.75 | 96 tests | Q99836 | RUO |
Abbexa | MYD88 | abx493014 | Human Myeloid Differentiation Primary Response Protein MyD88 (MYD88) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.055 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | MYD88 | abx152414 | Human Myeloid Differentiation Primary Response Protein MyD88 (MYD88) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 662.5 | 96 tests | RUO | |
Abbexa | MYD88 | abx251761 | Human Myeloid Differentiation Primary Response Protein MyD88 (MYD88) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 525 | 96 tests | Q99836 | RUO |
Abbexa | MYD88 | abx197319 | Human Myeloid Differentiation Primary Response Protein MyD88 (MYD88) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 618.75 | 96 tests | RUO | |
FineTest | MYD88 | EM0669 | Mouse Myd88(Myeloid differentiation primary response protein MyD88) ELISA Kit | mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 78.125-5000pg/ml | 96T | P22366 | RUO | ||
Abbexa | MYD88 | abx255019 | Mouse Myeloid Differentiation Primary Response Protein MyD88 (MYD88) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | 46.9 pg/ml | 562.5 | 96 tests | P22366 | RUO |
Abbexa | MYD88 | abx154422 | Mouse Myeloid Differentiation Primary Response Protein MyD88 (MYD88) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 675 | 96 tests | RUO | |
Abbexa | MYD88 | abx493015 | Mouse Myeloid Differentiation Primary Response Protein MyD88 (MYD88) CLIA Kit | Mouse | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.061 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | MYD88 | abx360554 | Pig Myeloid Differentiation Primary Response Protein MyD88 (MYD88) ELISA Kit | Pig | Serum,Plasma,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 687.5 | 96 tests | RUO | |
FineTest | MYD88 | ER1598 | Rat MyD88(myeloid differentiation factor 88) ELISA Kit | rat | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 78.125-5000pg/ml | 96T | Q6Y1S1 | RUO | ||
Abbexa | MYD88 | abx493016 | Rat Myeloid Differentiation Primary Response Protein MyD88 (MYD88) CLIA Kit | Rat | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 78 pg/ml - 5000 pg/ml | < 27 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | MYD88 | abx155851 | Rat Myeloid Differentiation Primary Response Protein MyD88 (MYD88) ELISA Kit | Rat | Serum,Plasma,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 27 pg/ml | 618.75 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | MYD88 | FNab10265 | anti- MYD88 antibody | human | monoclonal | Mouse | myeloid differentiation primary response gene | IgG1 | Unconjugated | ELISA, WB | 100µg | Q99836 | RUO | |
FineTest | MYD88 | FNab10314 | anti- MYD88 antibody | human | polyclonal | Rabbit | myeloid differentiation primary response gene | IgG | Unconjugated | ELISA, WB, IHC | 100µg | Q99836 | RUO | |
FineTest | MYD88 | FNab09835 | anti- MYD88 antibody | human | polyclonal | Rabbit | myeloid differentiation primary response gene | IgG | Unconjugated | ELISA, WB | 100µg | Q99836 | RUO | |
Abbexa | MYD88 | abx315496 | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody (Biotin) | Human | Polyclonal | Rabbit | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) | Biotin | ELISA | 162.5 | 20 µg | Q99836 | RUO | |
Abbexa | MYD88 | abx301040 | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody | Human | Polyclonal | Rabbit | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) | Unconjugated | ELISA, IF/ICC | 162.5 | 20 µg | Q99836 | RUO | |
Abbexa | MYD88 | abx431444 | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody (Biotin) | Human | Polyclonal | Goat | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) | Biotin | P-ELISA, WB, IHC | 387.5 | 200 µl | RUO | ||
Abbexa | MYD88 | abx315494 | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody (HRP) | Human | Polyclonal | Rabbit | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) | HRP | ELISA | 162.5 | 20 µg | Q99836 | RUO | |
Abbexa | MYD88 | abx177653 | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody | Human | Polyclonal | Rabbit | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO | ||
Abbexa | MYD88 | abx173652 | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody | Human | Monoclonal | Mouse | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) | Unconjugated | WB, IHC, IF/ICC | 750 | 1 ml | RUO | ||
Abbexa | MYD88 | abx315495 | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody (FITC) | Human | Polyclonal | Rabbit | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) | FITC | 162.5 | 20 µg | Q99836 | RUO | ||
Abbexa | MYD88 | abx137458 | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody | Human | Monoclonal | Mouse | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) | Unconjugated | 225 | 5 µg | RUO | |||
Abbexa | MYD88 | abx033978 | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody | Human | Polyclonal | Rabbit | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) | Unconjugated | ELISA, WB, IHC, FCM | 281.25 | 50 µl | Q99836 | RUO | |
Abbexa | MYD88 | abx431443 | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody | Human | Polyclonal | Goat | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) | Unconjugated | P-ELISA, WB, IHC, IF/ICC, FCM | 387.5 | 200 µl | RUO | ||
Abbexa | MYD88 | abx240069 | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody | Human | Monoclonal | Mouse | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) | Unconjugated | ELISA, WB | 350 | 100 µg | Q99836 | RUO | |
Abbexa | MYD88 | abx117017 | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody | Human | Polyclonal | Rabbit | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) | Unconjugated | ELISA, WB, IHC | 450 | 100 µl | Q99836 | RUO | |
Abbexa | MYD88 | abx147112 | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody | Human | Polyclonal | Rabbit | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) | Unconjugated | ELISA, WB | 350 | 100 µg | Q99836 | RUO | |
Abbexa | MYD88 | abx329675 | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody | Human | Polyclonal | Rabbit | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | Q99836 | RUO | |
Abbexa | MYD88 | abx000933 | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody | Human | Polyclonal | Rabbit | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) | Unconjugated | WB, IF/ICC | 175 | 20 µl | Q99836 | RUO | |
Abbexa | MYD88 | abx214751 | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody | Human | Polyclonal | Rabbit | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q99836 | RUO | |
Abbexa | MYD88 | abx147110 | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody | Human | Polyclonal | Rabbit | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | Q99836 | RUO | |
Abbexa | MYD88 | abx103640 | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody | Mouse | Polyclonal | Rabbit | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P22366 | RUO | |
Abbexa | MYD88 | abx173653 | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody | Rat | Monoclonal | Mouse | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) | Unconjugated | WB, IHC, IF/ICC | 812.5 | 1 ml | RUO | ||
Abbexa | MYD88 | abx130079 | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody | Rat | Polyclonal | Rabbit | Myeloid Differentiation Primary Response Protein MyD88 (MYD88) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | Q6Y1S1 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | MYD88 | abx654428 | Chicken Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Protein | Chicken | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 375 | 50 µg | RUO | |
Abbexa | MYD88 | abx654429 | Human Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | RUO | |
Abbexa | MYD88 | abx167730 | Rat Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO | |
Abbexa | MYD88 | abx261025 | Myeloid Differentiation Primary Response 88 Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 5 µg | Q99836 | RUO | ||
Abbexa | MYD88 | abx068126 | Mouse Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | P22366 | RUO |
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