Mouse Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Protein

Este producto es parte de MYD88 - Myeloid differentiation primary response 88
Mouse Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Protein

Pida mas información

935106861

info@markelab.com

Precio

247€ (10 µg)

Protein MYD88

proveedor

Abbexa

reference

abx068126

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Mouse Myeloid Differentiation Factor 88 (MyD88) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

MYD88 is a key adaptor protein involved in innate immune signaling downstream of Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). It contains a death domain (DD) and a Toll/IL-1 receptor (TIR) domain, enabling interaction with upstream receptors and downstream signaling proteins. Upon activation, MYD88 recruits IRAK kinases (IRAK1/IRAK4) and TRAF6, leading to activation of NF-κB, MAPK, and JNK pathways, which regulate inflammation, cytokine production, and cell survival. MYD88 is essential for host defense against bacterial, viral, and fungal infections. Mutations in MYD88 are associated with immune dysregulation, such as autoimmune diseases and lymphomas, including Waldenström macroglobulinemia. Knockout studies show impaired immune responses, increased susceptibility to infections, and defects in pro-inflammatory cytokine production, underscoring MYD88's central role in innate immunity.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Myeloid Differentiation Primary Response Protein MyD88 (MYD88)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 28.2 kDa Observed MW (SDS-PAGE): 28 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg32-Pro265 Tag: N-terminal His tag


expression

Recombinant


purity

> 97%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

MYD88


dry ice

No


availability

Shipped within 5-7 working days.


alias

MYD88D,MYD88 innate immune signal transduction adaptor, IMD68


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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