Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody

Este producto es parte de MYD88 - Myeloid differentiation primary response 88
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364€ (100 µg)

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935106861
info@markelab.com
name
Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx240069
tested applications
ELISA, WB

Description

Myeloid Differentiation Primary Response Protein MyD88 (MYD88) Antibody is a Mouse Monoclonal antibody for the detection of MYD88.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Myeloid Differentiation Primary Response Protein MyD88 (MYD88)
Host
Mouse
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1/1000 - 1/5000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Isotype
IgG1
Purity
≥ 95% (SDS-PAGE)
Purification
Purified by Protein A and Protein G affinity chromatography.
Size 1
100 µg
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Availability
Shipped within 5-12 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q99836
Gene ID
4615
OMIM
602170
Alias
MYD88D,MYD88 innate immune signal transduction adaptor, IMD68
Background
Antibody anti-MYD88
Status
RUO
Note
Concentration: 2 mg/ml - Validity: 12 months.

Descripción

MYD88 is a key adaptor protein involved in innate immune signaling downstream of Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). It contains a death domain (DD) and a Toll/IL-1 receptor (TIR) domain, enabling interaction with upstream receptors and downstream signaling proteins. Upon activation, MYD88 recruits IRAK kinases (IRAK1/IRAK4) and TRAF6, leading to activation of NF-κB, MAPK, and JNK pathways, which regulate inflammation, cytokine production, and cell survival. MYD88 is essential for host defense against bacterial, viral, and fungal infections. Mutations in MYD88 are associated with immune dysregulation, such as autoimmune diseases and lymphomas, including Waldenström macroglobulinemia. Knockout studies show impaired immune responses, increased susceptibility to infections, and defects in pro-inflammatory cytokine production, underscoring MYD88's central role in innate immunity.

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