Mouse Myeloid Differentiation Primary Response Protein MyD88 (MYD88) ELISA Kit

Este producto es parte de MYD88 - Myeloid differentiation primary response 88
Mouse Myeloid Differentiation Primary Response Protein MyD88 (MYD88) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

585€ (96 tests)

Elisa kits for MYD88

proveedor

Abbexa

reference

abx255019

Tested Applications

ELISA

reactivity

Mouse

status

RUO

clonality

Descripción

Mouse Myeloid Differentiation Primary Response Protein MyD88 (MYD88) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Myeloid Differentiation Primary Response Protein MyD88 (MYD88) concentrations in tissue homogenates, cell lysates and other biological fluids.

Background

MYD88 is a key adaptor protein involved in innate immune signaling downstream of Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). It contains a death domain (DD) and a Toll/IL-1 receptor (TIR) domain, enabling interaction with upstream receptors and downstream signaling proteins. Upon activation, MYD88 recruits IRAK kinases (IRAK1/IRAK4) and TRAF6, leading to activation of NF-κB, MAPK, and JNK pathways, which regulate inflammation, cytokine production, and cell survival. MYD88 is essential for host defense against bacterial, viral, and fungal infections. Mutations in MYD88 are associated with immune dysregulation, such as autoimmune diseases and lymphomas, including Waldenström macroglobulinemia. Knockout studies show impaired immune responses, increased susceptibility to infections, and defects in pro-inflammatory cytokine production, underscoring MYD88's central role in innate immunity.

Características del producto

category

ELISA Kits

immunogen target

Myeloid Differentiation Primary Response Protein MyD88 (MYD88)

reactivity

Mouse

test range

78 pg/ml - 5000 pg/ml

sensitivity

46.9 pg/ml

assay type

Sandwich

assay data

Quantitative

form

Lyophilized

detection method

Colorimetric

sample type

Tissue homogenates, cell lysates and other biological fluids.

size 1

96 tests

size 2

5 × 96 tests

size 3

10 × 96 tests

alias

MYD88D,MYD88 innate immune signal transduction adaptor, IMD68

storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

or code

MYD88

dry ice

No

uniprot id

https://www.uniprot.org/uniprotkb/P22366

note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

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