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Melanin Concentrating Hormone Receptor (MCHR), also known as MCH1 receptor, is a G protein-coupled receptor (GPCR) that binds to melanin-concentrating hormone (MCH). MCHR is primarily expressed in the central nervous system and plays a role in regulating various physiological processes, including feeding behavior, energy homeostasis, and mood. The primary ligand for MCHR is melanin-concentrating hormone (MCH), a neuropeptide produced by neurons in the lateral hypothalamus. MCH binds to and activates MCHR, initiating intracellular signaling pathways.
MCHR, like other GPCRs, possesses seven transmembrane domains, an extracellular N-terminus, and an intracellular C-terminus. It also contains binding sites for G proteins, which mediate downstream signaling upon receptor activation.
MCHR is involved in the regulation of various physiological processes, including:
Regulation of feeding behavior and appetite
Modulation of energy expenditure and metabolism
Regulation of sleep-wake cycles
Modulation of stress responses
Regulation of emotional behaviors and mood
Dysregulation of MCHR signaling has been implicated in several diseases and pathological conditions, including obesity, depression, anxiety disorders, and sleep disorders. Aberrant MCHR signaling can contribute to the pathogenesis of these disorders by disrupting normal regulation of feeding behavior, energy homeostasis, and mood.
MCHR has emerged as a potential therapeutic target for the treatment of obesity, depression, and other neuropsychiatric disorders. Modulating MCHR signaling could offer therapeutic benefits by regulating appetite, energy metabolism, and mood. Several pharmacological agents targeting MCHR, including selective agonists and antagonists, are currently under investigation in preclinical and clinical studies as potential therapeutics. Selective modulation of MCHR signaling holds the potential to provide targeted therapy with minimal side effects on other physiological processes.
Melanin Concentrating Hormone Receptor 1 (MCHR1)
MCHR1,GPR24,MCH-1R,MCH1R,SLC-1,SLC1,G protein-coupled receptor 24,MCH receptor 1,somatostatin receptor-like protein
Melanin Concentrating Hormone Receptor 2 (MCHR2)
MCHR2,GPR145,GPRv17,MCH-2R,MCH-R2,MCH2,MCH2R,MCHR-2,SLT,G protein-coupled receptor 145,melanin-concentrating hormone receptor 2
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, CLIA Kits, ELISA Kits, Primary Antibodies) relacionados con MCHR - Melanin Concentrating Hormone Receptor
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 25 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | MCHR1 | EH1306 | Human MCHR1(Melanin-concentRating hormone receptor 1) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.313-20ng/ml | 96T | Q99705 | RUO | ||
FineTest | MCHR2 | EH1309 | Human MCHR2(Melanin-concentRating hormone receptor 2) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | Q969V1 | RUO | ||
Abbexa | MCHR1 | abx493997 | Human Melanin Concentrating Hormone Receptor 1 (MCHR1) CLIA Kit | Human | Tissue homogenates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.109 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | MCHR1 | abx055009 | Human Melanin Concentrating Hormone Receptor 1 (MCHR1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | 0.19 ng/ml | 562.5 | 96 tests | Q99705 | RUO |
Abbexa | MCHR1 | abx152286 | Human Melanin Concentrating Hormone Receptor 1 (MCHR1) ELISA Kit | Human | Tissue homogenates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.11 ng/ml | 687.5 | 96 tests | Q99705 | RUO |
Abbexa | MCHR2 | abx250574 | Human Melanin Concentrating Hormone Receptor 2 (MCHR2) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q969V1 | RUO | |
Abbexa | MCHR1 | abx515457 | Mouse Melanin Concentrating Hormone Receptor 1 (MCHR1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.78 ng/ml - 50 ng/ml | 687.5 | 96 tests | Q8JZL2 | RUO | |
Abbexa | MCHR1 | abx515458 | Pig Melanin Concentrating Hormone Receptor 1 (MCHR1) ELISA Kit | Pig | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9MZ01 | RUO | ||
Abbexa | MCHR1 | abx515459 | Rat Melanin Concentrating Hormone Receptor 1 (MCHR1) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.78 ng/ml - 50 ng/ml | 687.5 | 96 tests | P97639 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | MCHR1 | FNab05050 | anti- MCHR1 antibody | human | polyclonal | Rabbit | melanin-concentrating hormone receptor 1 | IgG | Unconjugated | ELISA, WB, IHC | 100µg | Q99705 | RUO | |
FineTest | MCHR1 | FNab05051 | anti- MCHR1 antibody | human | polyclonal | Rabbit | melanin-concentrating hormone receptor 1 | IgG | Unconjugated | ELISA, WB, IHC | 100µg | Q99705 | RUO | |
Abbexa | MCHR1 | abx324323 | Melanin Concentrating Hormone Receptor 2 (MCHR2) Antibody | Human | Polyclonal | Rabbit | Melanin Concentrating Hormone Receptor 2 (MCHR2) | Unconjugated | ELISA, WB, IF/ICC | 187.5 | 50 µg | Q969V1 | RUO | |
Abbexa | MCHR1 | abx025849 | Melanin Concentrating Hormone Receptor 1 (MCHR1) Antibody | Human | Polyclonal | Rabbit | Melanin Concentrating Hormone Receptor 1 (MCHR1) | Unconjugated | ELISA, WB, IHC, FCM | 281.25 | 80 µl | Q99705 | RUO | |
Abbexa | MCHR1 | abx235050 | Melanin Concentrating Hormone Receptor 1 (MCHR1) Antibody | Human | Polyclonal | Rabbit | Melanin Concentrating Hormone Receptor 1 (MCHR1) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | Q99705 | RUO | |
Abbexa | MCHR1 | abx242225 | Melanin Concentrating Hormone Receptor 1 (MCHR1) Antibody | Human | Polyclonal | Rabbit | Melanin Concentrating Hormone Receptor 1 (MCHR1) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q99705 | RUO | |
Abbexa | MCHR1 | abx235051 | Melanin Concentrating Hormone Receptor 1 (MCHR1) Antibody | Human | Polyclonal | Rabbit | Melanin Concentrating Hormone Receptor 1 (MCHR1) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | Q99705 | RUO | |
Abbexa | MCHR1 | abx113654 | Melanin Concentrating Hormone Receptor 1 (MCHR1) Antibody | Human | Polyclonal | Rabbit | Melanin Concentrating Hormone Receptor 1 (MCHR1) | Unconjugated | ELISA, WB | 612.5 | 100 µl | Q99705 | RUO | |
Abbexa | MCHR1 | abx242224 | Melanin Concentrating Hormone Receptor 1 (MCHR1) Antibody | Human | Polyclonal | Rabbit | Melanin Concentrating Hormone Receptor 1 (MCHR1) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q99705 | RUO | |
Abbexa | MCHR2 | abx334043 | Melanin Concentrating Hormone Receptor 2 (MCHR2) Antibody | Human | Polyclonal | Rabbit | Melanin Concentrating Hormone Receptor 2 (MCHR2) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | Q969V1 | RUO | |
Abbexa | MCHR2 | abx336465 | Melanin Concentrating Hormone Receptor 2 (MCHR2) Antibody (HRP) | Human | Polyclonal | Rabbit | Melanin Concentrating Hormone Receptor 2 (MCHR2) | HRP | ELISA | 162.5 | 20 µg | Q969V1 | RUO | |
Abbexa | MCHR2 | abx336467 | Melanin Concentrating Hormone Receptor 2 (MCHR2) Antibody (Biotin) | Human | Polyclonal | Rabbit | Melanin Concentrating Hormone Receptor 2 (MCHR2) | Biotin | ELISA | 162.5 | 20 µg | Q969V1 | RUO | |
Abbexa | MCHR2 | abx336466 | Melanin Concentrating Hormone Receptor 2 (MCHR2) Antibody (FITC) | Human | Polyclonal | Rabbit | Melanin Concentrating Hormone Receptor 2 (MCHR2) | FITC | 162.5 | 20 µg | Q969V1 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | MCHR1 | abx654332 | Human Melanin Concentrating Hormone Receptor 1 (MCHR1) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 1800 | 1 mg | RUO | |
Abbexa | MCHR1 | abx651269 | Human Melanin Concentrating Hormone Receptor 1 (MCHR1) Peptide (OVA) | Human | Synthetic | OVA | WB, SDS-PAGE | 425 | 100 µg | RUO | ||
FineTest | MCHR1 | P2075 | Recombinant Human MCHR1 | Human | Recombinant | E.Coli | Western Blot, ELISA | 50μg | Q99705 | RUO |
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