MCHR - Melanin Concentrating Hormone Receptor | Elisa - Clia - Antibody - Protein

Background:

Melanin Concentrating Hormone Receptor (MCHR), also known as MCH1 receptor, is a G protein-coupled receptor (GPCR) that binds to melanin-concentrating hormone (MCH). MCHR is primarily expressed in the central nervous system and plays a role in regulating various physiological processes, including feeding behavior, energy homeostasis, and mood. The primary ligand for MCHR is melanin-concentrating hormone (MCH), a neuropeptide produced by neurons in the lateral hypothalamus. MCH binds to and activates MCHR, initiating intracellular signaling pathways.

Structural Features:

MCHR, like other GPCRs, possesses seven transmembrane domains, an extracellular N-terminus, and an intracellular C-terminus. It also contains binding sites for G proteins, which mediate downstream signaling upon receptor activation.

Physiological Functions:

MCHR is involved in the regulation of various physiological processes, including:

Regulation of feeding behavior and appetite

Modulation of energy expenditure and metabolism

Regulation of sleep-wake cycles

Modulation of stress responses

Regulation of emotional behaviors and mood

Clinical Implications:

Dysregulation of MCHR signaling has been implicated in several diseases and pathological conditions, including obesity, depression, anxiety disorders, and sleep disorders. Aberrant MCHR signaling can contribute to the pathogenesis of these disorders by disrupting normal regulation of feeding behavior, energy homeostasis, and mood.

Therapeutic Potential:

MCHR has emerged as a potential therapeutic target for the treatment of obesity, depression, and other neuropsychiatric disorders. Modulating MCHR signaling could offer therapeutic benefits by regulating appetite, energy metabolism, and mood. Several pharmacological agents targeting MCHR, including selective agonists and antagonists, are currently under investigation in preclinical and clinical studies as potential therapeutics. Selective modulation of MCHR signaling holds the potential to provide targeted therapy with minimal side effects on other physiological processes.