Human Melanin Concentrating Hormone Receptor 2 (MCHR2) ELISA Kit

Este producto es parte de MCHR - Melanin Concentrating Hormone Receptor
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715€ (96 tests)

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935106861
info@markelab.com
name
Human Melanin Concentrating Hormone Receptor 2 (MCHR2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx250574
tested applications
ELISA

Description

Human Melanin Concentrating Hormone Receptor 2 (MCHR2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Melanin-concentrating hormone receptor 2 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
Melanin Concentrating Hormone Receptor 2 (MCHR2)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-12 working days. The validity for this kit is 6 months.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q969V1
Alias
MCHR2,GPR145,GPRv17,MCH-2R,MCH-R2,MCH2,MCH2R,MCHR-2,SLT,G protein-coupled receptor 145,melanin-concentrating hormone receptor 2
Background
Elisa kits for MCHR2
Status
RUO
Note
Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

MCHR2 is another G protein-coupled receptor for melanin-concentrating hormone (MCH), but unlike MCHR1, it is functionally expressed only in humans and other primates. MCHR2 primarily signals through Gq proteins, activating phospholipase C (PLC) and increasing intracellular calcium levels, which influences neuronal excitability and cellular responses. MCHR2 is expressed in the brain, particularly in regions regulating feeding, energy homeostasis, and mood, where it complements MCHR1’s actions. Activation of MCHR2 stimulates appetite and energy storage, linking it to obesity and metabolic dysregulation. Additionally, MCHR2 is implicated in emotional regulation, with potential roles in stress response and anxiety. Dysregulation of MCHR2 has been associated with overeating and weight gain, making it a target for anti-obesity therapies. Due to its restricted expression in humans and primates, MCHR2 represents a species-specific target with therapeutic potential in metabolic and mood disorders. The development of selective MCHR2 modulators could provide novel approaches to treating obesity and emotional dysregulation.

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