Human Melanin Concentrating Hormone Receptor 1 (MCHR1) Protein

Product specifications

Proteins and Peptides

Melanin Concentrating Hormone Receptor 1 (MCHR1)

E. coli

Human

Unconjugated

Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Please enquire.
Tag: N-terminal His tag

Recombinant

> 90%

1 mg

5 mg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 1-2 months.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

MCHR1,GPR24,MCH-1R,MCH1R,SLC-1,SLC1,G protein-coupled receptor 24,MCH receptor 1,somatostatin receptor-like protein

Protein MCHR1

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

MCHR1 is a G protein-coupled receptor (GPCR) activated by melanin-concentrating hormone (MCH), a neuropeptide involved in energy homeostasis, feeding behavior, and emotional regulation. MCHR1 is widely expressed in the central nervous system (CNS), particularly in regions such as the hypothalamus, hippocampus, and cerebral cortex, where it mediates the effects of MCH on appetite stimulation, energy storage, and mood regulation. MCHR1 primarily signals through Gi/o proteins, inhibiting adenylate cyclase activity and reducing cyclic AMP (cAMP) levels, while also activating MAPK and calcium signaling pathways. Dysregulation of MCHR1 is associated with obesity, metabolic disorders, and psychiatric conditions, such as depression and anxiety, due to its role in regulating energy balance and mood. Pharmacological antagonists of MCHR1 are being developed as potential treatments for obesity by suppressing appetite and reducing energy storage, while agonists may have applications in mood disorders. MCHR1’s involvement in feeding, energy metabolism, and emotional regulation highlights its therapeutic significance in metabolic and neurological disorders.

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