Melanin Concentrating Hormone Receptor 2 (MCHR2) Antibody
169€ (20 µg)
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935106861
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name
Melanin Concentrating Hormone Receptor 2 (MCHR2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx334043
tested applications
ELISA, IHC, IF/ICC
Description
MCHR2 Antibody is a Rabbit Polyclonal against MCHR2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Melanin Concentrating Hormone Receptor 2 (MCHR2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/200 - 1/500, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q969V1 |
| Gene ID | 84539 |
| Alias | MCHR2,GPR145,GPRv17,MCH-2R,MCH-R2,MCH2,MCH2R,MCHR-2,SLT,G protein-coupled receptor 145,melanin-concentrating hormone receptor 2 |
| Background | Antibody anti-MCHR2 |
| Status | RUO |
Descripción
MCHR2 is another G protein-coupled receptor for melanin-concentrating hormone (MCH), but unlike MCHR1, it is functionally expressed only in humans and other primates. MCHR2 primarily signals through Gq proteins, activating phospholipase C (PLC) and increasing intracellular calcium levels, which influences neuronal excitability and cellular responses. MCHR2 is expressed in the brain, particularly in regions regulating feeding, energy homeostasis, and mood, where it complements MCHR1’s actions. Activation of MCHR2 stimulates appetite and energy storage, linking it to obesity and metabolic dysregulation. Additionally, MCHR2 is implicated in emotional regulation, with potential roles in stress response and anxiety. Dysregulation of MCHR2 has been associated with overeating and weight gain, making it a target for anti-obesity therapies. Due to its restricted expression in humans and primates, MCHR2 represents a species-specific target with therapeutic potential in metabolic and mood disorders. The development of selective MCHR2 modulators could provide novel approaches to treating obesity and emotional dysregulation.
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