Family main features
IL6R is found on the surface of many types of cells, including immune cells like T cells, B cells, and macrophages, as well as non-immune cells like hepatocytes (liver cells) and endothelial cells (cells lining blood vessels).The IL6R is a transmembrane glycoprotein composed a extracellular Domain that contains the binding site for interleukin-6 (IL-6). It consists of two cytokine receptor homology domains (CRH1 and CRH2) responsible for IL-6 binding.A transmembrane Domain Anchoring the receptor in the cell membrane, And a Intracellular Domain Involved in signal transduction upon IL-6 binding, initiating downstream signaling cascades. The IL6R mediates the biological effects of IL-6 by binding to it and initiating intracellular signaling pathways. Upon IL-6 binding, the IL6R undergoes conformational changes that lead to the recruitment of a co-receptor called gp130, forming a functional signaling complex. This complex activates various downstream signaling pathways, including the Janus kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway, the mitogen-activated protein kinase (MAPK) pathway, and the phosphatidylinositol 3-kinase (PI3K) pathway.The signaling initiated by IL-6 through its receptor is involved in numerous physiological processes, including: Regulation of immune responses, Hematopoiesis,Metabolic regulation,Neural development.
IL6R is a type I membrane glycoprotein that consists of two main forms: a membrane-bound form (mIL6R) and a soluble form (sIL6R). The membrane-bound IL6R is composed of three main domains:
The soluble form (sIL6R) arises from proteolytic cleavage of the membrane-bound receptor or through alternative splicing of IL6R mRNA. Both forms can bind IL-6, but their roles in signaling differ.
IL6R is classified under the cytokine receptor superfamily, particularly the IL-6 receptor family. This family also includes receptors for other cytokines such as IL-11, IL-27, and leukemia inhibitory factor (LIF). The receptor family is characterized by their association with the glycoprotein 130 (gp130) signal-transducing subunit.
IL6R mediates the effects of IL-6 through its interaction with gp130, which is ubiquitously expressed on cell surfaces. The IL-6/IL6R/gp130 complex triggers intracellular signaling cascades, including:
IL6R signaling is involved in:
Interleukin 6 receptor (IL6R) is a critical component of the IL-6 signaling pathway, playing a significant role in immune response, inflammation, and hematopoiesis. It exists in both membrane-bound and soluble forms, each contributing differently to IL-6 signaling. Dysregulated IL6R signaling is linked to various inflammatory diseases and cancers, making it a valuable therapeutic target. Understanding IL6R's structure, function, and interactions is essential for developing effective treatments for conditions associated with abnormal IL-6 signaling.
Interleukin 6 Receptor (IL6R)
IL6Q,gp80,CD126,HIES5,IL-6R,IL6RA,IL6RQ,IL-1Ra,IL-6RA,IL6QTL,IL-6R-1,L-6R-Alpha,IL-6Rα
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, CLIA Kits, ELISA Kits) relacionados con IL6R - Interleukin 6 Receptor
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Esta página contiene 51 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | IL6R | EH0202 | Human IL-6Rα(Interleukin-6 receptor subunit alpha) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 31.25-2000pg/ml | 96T | P08887 | RUO | ||
Abbexa | IL6R | abx195908 | Human Interleukin 6 Receptor (IL6R) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 12.5 pg/ml - 800 pg/ml | 7.5 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | IL6R | abx253572 | Human Interleukin 6 Receptor (IL6R) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 493.75 | 96 tests | P08887 | RUO |
Abbexa | IL6R | abx493109 | Human Interleukin 6 Receptor (IL6R) CLIA Kit | Human | Serum, plasma, tissue homogenates, urine and other biological fluids. | Sandwich | 1.88 ng/ml - 120 ng/ml | < 0.83 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | IL6R | abx151950 | Human Interleukin 6 Receptor (IL6R) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 1.88 ng/ml - 120 ng/ml | < 0.67 ng/ml | 662.5 | 96 tests | RUO | |
Abbexa | IL6R | abx257871 | Monkey Interleukin 6 Receptor (IL6R) ELISA Kit | Monkey | Serum,Plasma,Other biological fluids | Sandwich | 125 pg/ml - 8000 pg/ml | 75 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | IL6R | abx154201 | Mouse Interleukin 6 Receptor (IL6R) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.13 ng/ml | 675 | 96 tests | RUO | |
Abbexa | IL6R | abx254422 | Mouse Interleukin 6 Receptor (IL6R) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 587.5 | 96 tests | P22272, Q00560 | RUO |
Abbexa | IL6R | abx493110 | Mouse Interleukin 6 Receptor (IL6R) CLIA Kit | Mouse | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.125 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | IL6R | abx361793 | Pig Interleukin 6 Receptor (IL6R) ELISA Kit | Pig | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 662.5 | 96 tests | O18796 | RUO |
FineTest | IL6R | ER1105 | Rat IL-6R(Interleukin 6 Receptor) ELISA Kit | rat | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 78.125-5000pg/ml | 96T | P22273 | RUO | ||
Abbexa | IL6R | abx255770 | Rat Interleukin 6 Receptor (IL6R) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | 46.9 pg/ml | 525 | 96 tests | P22273 | RUO |
Abbexa | IL6R | abx195909 | Rat Interleukin 6 Receptor (IL6R) CLIA Kit | Rat | Serum, plasma and other biological fluids. | Sandwich | 15.6 pg/ml - 1000 pg/ml | 9.38 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | IL6R | abx155686 | Rat Interleukin 6 Receptor (IL6R) ELISA Kit | Rat | Serum,Plasma,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | IL6R | abx493111 | Rat Interleukin 6 Receptor (IL6R) CLIA Kit | Rat | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.067 ng/ml | 812.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | IL6R | abx431356 | Interleukin 6 Receptor (IL6R) Antibody | Polyclonal | Goat | Interleukin 6 Receptor (IL6R) | Unconjugated | P-ELISA | 250 | 200 µl | RUO | |||
FineTest | IL6R | FNab04284 | anti- IL6R antibody | human | polyclonal | Rabbit | interleukin 6 receptor | IgG | Unconjugated | ELISA, WB, IHC, IP | 100µg | P08887 | RUO | |
Abbexa | IL6R | abx415559 | Interleukin 6 Receptor (IL6R) Antibody | Human | Monoclonal | Mouse | Interleukin 6 Receptor (IL6R) | Unconjugated | ELISA, IHC, IF/ICC, FCM, IP | 337.5 | 100 µg | P08887 | RUO | |
Abbexa | IL6R | abx323401 | Interleukin 6 Receptor (IL6R) Antibody | Human | Polyclonal | Rabbit | Interleukin 6 Receptor (IL6R) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P08887 | RUO | |
Abbexa | IL6R | abx037368 | Interleukin 6 Receptor (IL6R) Antibody | Human | Polyclonal | Rabbit | Interleukin 6 Receptor (IL6R) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | IL6R | abx145626 | Interleukin 6 Receptor (IL6R) Antibody | Human | Polyclonal | Rabbit | Interleukin 6 Receptor (IL6R) | Unconjugated | ELISA, WB | 337.5 | 100 µg | RUO | ||
Abbexa | IL6R | abx102264 | Interleukin 6 Receptor (IL6R) Antibody | Human | Polyclonal | Rabbit | Interleukin 6 Receptor (IL6R) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P08887 | RUO | |
Abbexa | IL6R | abx272194 | Interleukin 6 Receptor (IL6R) Antibody (Biotin) | Human | Polyclonal | Rabbit | Interleukin 6 Receptor (IL6R) | Biotin | WB, IHC, IF/ICC | 350 | 200 µl | RUO | ||
Abbexa | IL6R | abx173186 | Interleukin 6 Receptor (IL6R) Antibody | Human | Monoclonal | Mouse | Interleukin 6 Receptor (IL6R) | Unconjugated | WB, IHC, IF/ICC | 750 | 1 ml | RUO | ||
Abbexa | IL6R | abx234284 | Interleukin 6 Receptor (IL6R) Antibody | Human | Polyclonal | Rabbit | Interleukin 6 Receptor (IL6R) | Unconjugated | ELISA, WB, IHC, IP | 350 | 100 µg | P08887 | RUO | |
Abbexa | IL6R | abx001321 | Interleukin 6 Receptor (IL6R) Antibody | Human | Polyclonal | Rabbit | Interleukin 6 Receptor (IL6R) | Unconjugated | WB, IHC | 175 | 20 µl | P08887 | RUO | |
Abbexa | IL6R | abx102265 | Interleukin 6 Receptor (IL6R) Antibody | Mouse | Polyclonal | Rabbit | Interleukin 6 Receptor (IL6R) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P22272 | RUO | |
Abbexa | IL6R | abx102266 | Interleukin 6 Receptor (IL6R) Antibody | Mouse | Polyclonal | Rabbit | Interleukin 6 Receptor (IL6R) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P22272 | RUO | |
Abbexa | IL6R | abx272798 | Interleukin 6 Receptor (IL6R) Antibody (Biotin) | Mouse | Polyclonal | Rabbit | Interleukin 6 Receptor (IL6R) | Biotin | WB, IHC, IF/ICC | 362.5 | 200 µl | RUO | ||
Abbexa | IL6R | abx274554 | Interleukin 6 Receptor (IL6R) Antibody (Biotin) | Rat | Polyclonal | Rabbit | Interleukin 6 Receptor (IL6R) | Biotin | WB, IHC, IF/ICC | 375 | 200 µl | RUO | ||
Abbexa | IL6R | abx102269 | Interleukin 6 Receptor (IL6R) Antibody | Rat | Polyclonal | Rabbit | Interleukin 6 Receptor (IL6R) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | P22273 | RUO | |
Abbexa | IL6R | abx130196 | Interleukin 6 Receptor (IL6R) Antibody | Rat | Polyclonal | Rabbit | Interleukin 6 Receptor (IL6R) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | P22273 | RUO | |
Abbexa | IL6R | abx177196 | Interleukin 6 Receptor (IL6R) Antibody | Rat | Polyclonal | Rabbit | Interleukin 6 Receptor (IL6R) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | IL6R | abx102267 | Interleukin 6 Receptor (IL6R) Antibody | Rat | Polyclonal | Rabbit | Interleukin 6 Receptor (IL6R) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | P22273 | RUO | |
Abbexa | IL6R | abx273266 | Interleukin 6 Receptor (IL6R) Antibody (Biotin) | Rat | Polyclonal | Rabbit | Interleukin 6 Receptor (IL6R) | Biotin | WB, IHC, IF/ICC | 375 | 200 µl | RUO | ||
Abbexa | IL6R | abx130195 | Interleukin 6 Receptor (IL6R) Antibody | Rat | Polyclonal | Rabbit | Interleukin 6 Receptor (IL6R) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | P22273 | RUO | |
Abbexa | IL6R | abx102268 | Interleukin 6 Receptor (IL6R) Antibody | Rat | Polyclonal | Rabbit | Interleukin 6 Receptor (IL6R) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | P22273 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | IL6R | abx067543 | Human Interleukin 6 Receptor (IL6R) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | P08887 | RUO |
Abbexa | IL6R | abx682084 | Human Interleukin 6 Soluble Receptor (IL6SR) Protein | Human | Recombinant | E. coli | Unconjugated | SDS-PAGE | 325 | 10 µg | RUO | |
Abbexa | IL6R | abx694181 | Human Interleukin 6 Receptor Subunit Alpha (IL6R) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 300 | 20 µg | P08887 | RUO | |
Abbexa | IL6R | abx694272 | Mouse Interleukin 6 Receptor Subunit Alpha (IL6RA) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 462.5 | 20 µg | P22272 | RUO | |
Abbexa | IL6R | abx067548 | Rat Interleukin 6 Receptor (IL6R) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | P22273 | RUO |
Abbexa | IL6R | abx266289 | IL6R (partial) Peptide | Unconjugated | 312.5 | 5 mg | RUO | |||||
Abbexa | IL6R | abx167762 | Rat Interleukin 6 Receptor (IL6R) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | P22273 | RUO |
Abbexa | IL6R | abx651400 | Mouse Interleukin 6 Receptor (IL6R) Protein (Active) | Mouse | Unconjugated | WB, SDS-PAGE | 437.5 | 50 µg | P22272 | RUO | ||
Abbexa | IL6R | abx067546 | Rat Interleukin 6 Receptor (IL6R) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | P22273 | RUO |
Abbexa | IL6R | abx067545 | Mouse Interleukin 6 Receptor (IL6R) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 2337.5 | 1 mg | P22272 | RUO |
FineTest | IL6R | P1832 | Recombinant Human IL6R | Human | Recombinant | E.Coli | Western Blot, ELISA | 50μg | P08887 | RUO | ||
Abbexa | IL6R | abx691945 | Mouse Interleukin 6 Receptor (IL6R) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 50 µg | RUO | ||
Abbexa | IL6R | abx067544 | Mouse Interleukin 6 Receptor (IL6R) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | P22272 | RUO |
Abbexa | IL6R | abx167763 | Rat Interleukin 6 Receptor (IL6R) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | RUO |
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