Mouse Interleukin 6 Receptor (IL6R) Protein
1079€ (50 µg)
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935106861
info@markelab.com
name
Mouse Interleukin 6 Receptor (IL6R) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691945
tested applications
SDS-PAGE
Description
Mouse IL6RA Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mouse IL6Rα (NP_034689.2) extracellular domain (Ile 44-Glu 357) was expressed, with a C-terminal polyhistidine tag.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | IL6RA |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 39 kDa Sequence Fragment: Ile44-Glu357 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 97% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_034689.2 |
| Alias | IL6Q,gp80,CD126,HIES5,IL-6R,IL6RA,IL6RQ,IL-1Ra,IL-6RA,IL6QTL,IL-6R-1,L-6R-Alpha,IL-6Rα |
| Background | Protein IL6R |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
IL6R is a key component of the interleukin-6 (IL6) signaling pathway, consisting of a membrane-bound and soluble form (sIL6R), which binds IL6 and mediates downstream effects via the gp130 co-receptor This interaction activates the JAK/STAT3, MAPK, and PI3K/AKT pathways, regulating immune responses, inflammation, and hematopoiesis IL6R signaling is critical in acute-phase responses, B cell maturation, and T cell proliferation Dysregulation of IL6R activity is implicated in chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and systemic lupus erythematosus (SLE) In cancer, IL6R signaling supports tumor progression, angiogenesis, and immune evasion Therapeutic targeting of IL6R, such as with tocilizumab, is effective in reducing inflammation and cytokine storm in conditions like COVID-19, autoimmune disorders, and hematological malignancies
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