Interleukin 6 Receptor (IL6R) Antibody
351€ (100 µg)
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935106861
info@markelab.com
name
Interleukin 6 Receptor (IL6R) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx415559
tested applications
ELISA, IHC, IF/ICC, FCM, IP
Description
Interleukin-6 Receptor Subunit Alpha (CD126) Antibody is a Mouse Monoclonal antibody against Interleukin-6 Receptor Subunit Alpha (CD126).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Interleukin 6 Receptor (IL6R) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | FCM: 1/50 (It is recommended to use 10 µl of the suggested working dilution to label 106 cells in 100 µl). Validated in IHC-F, not tested in IHC-P. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | D218 |
| Purification | Purified from tissue culture supernatant by Protein A chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC, IF/ICC, FCM, IP |
| Buffer | PBS, containing 0.09% sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08887 |
| Alias | IL6Q,gp80,CD126,HIES5,IL-6R,IL6RA,IL6RQ,IL-1Ra,IL-6RA,IL6QTL,IL-6R-1,L-6R-Alpha,IL-6Rα |
| Background | Antibody anti-IL6R |
| Status | RUO |
| Note | Concentration: 1.0 mg/ml - |
Descripción
IL6R is a key component of the interleukin-6 (IL6) signaling pathway, consisting of a membrane-bound and soluble form (sIL6R), which binds IL6 and mediates downstream effects via the gp130 co-receptor This interaction activates the JAK/STAT3, MAPK, and PI3K/AKT pathways, regulating immune responses, inflammation, and hematopoiesis IL6R signaling is critical in acute-phase responses, B cell maturation, and T cell proliferation Dysregulation of IL6R activity is implicated in chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and systemic lupus erythematosus (SLE) In cancer, IL6R signaling supports tumor progression, angiogenesis, and immune evasion Therapeutic targeting of IL6R, such as with tocilizumab, is effective in reducing inflammation and cytokine storm in conditions like COVID-19, autoimmune disorders, and hematological malignancies
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