Mouse Interleukin 6 Receptor Subunit Alpha (IL6RA) Protein

Este producto es parte de IL6R - Interleukin 6 Receptor
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481€ (20 µg)

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935106861
info@markelab.com
name
Mouse Interleukin 6 Receptor Subunit Alpha (IL6RA) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx694272
tested applications
SDS-PAGE

Description

Mouse Interleukin 6 Receptor Subunit Alpha (IL6RA) Protein is a recombinant Mouse protein expressed in HEK293 cells.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Host
HEK293 cells
Origin
Mouse
Observed MW
Molecular Weight: Calculated MW: 39.16 kDa  Observed MW (SDS-PAGE): 58 kDa
Sequence Fragment: Met1-Glu357
Tag: C-terminal His tag
Expression
Recombinant
Purity
>95% (SDS-PAGE)
Size 1
20 µg
Size 2
100 µg
Form
Lyophilized Reconstitute in sterile H2O. Do not vortex.
Tested Applications
SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80.
Availability
Shipped within 5-15 working days.
Storage
Store lyophilized between -20 °C and -80 °C.
Dry Ice
No
UniProt ID
P22272
Gene ID
16194
Alias
IL6Q,gp80,CD126,HIES5,IL-6R,IL6RA,IL6RQ,IL-1Ra,IL-6RA,IL6QTL,IL-6R-1,L-6R-Alpha,IL-6Rα
Background
Protein IL6R
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

IL6R is a key component of the interleukin-6 (IL6) signaling pathway, consisting of a membrane-bound and soluble form (sIL6R), which binds IL6 and mediates downstream effects via the gp130 co-receptor This interaction activates the JAK/STAT3, MAPK, and PI3K/AKT pathways, regulating immune responses, inflammation, and hematopoiesis IL6R signaling is critical in acute-phase responses, B cell maturation, and T cell proliferation Dysregulation of IL6R activity is implicated in chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and systemic lupus erythematosus (SLE) In cancer, IL6R signaling supports tumor progression, angiogenesis, and immune evasion Therapeutic targeting of IL6R, such as with tocilizumab, is effective in reducing inflammation and cytokine storm in conditions like COVID-19, autoimmune disorders, and hematological malignancies

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