Family main features
Interleukin-36 beta (IL-36β), also known as IL-1F8, is part of the interleukin-1 (IL-1) cytokine family, which is pivotal in regulating inflammatory and immune responses. IL-36β is primarily expressed in epithelial tissues, including the skin, lungs, and gastrointestinal tract. Its primary role involves mediating inflammatory responses, particularly in skin-related conditions like psoriasis. IL-36β is released in response to cellular stress or damage and interacts with the IL-36 receptor (IL-36R), composed of IL-1 receptor-like 2 (IL1RL2) and IL-1 receptor accessory protein (IL1RAcP). This interaction triggers signaling pathways, notably NF-κB and MAPK, leading to the production of various pro-inflammatory cytokines and chemokines. IL-36β's functions and regulatory mechanisms make it significant in both innate and adaptive immunity.
IL-36β is synthesized as a precursor protein that must undergo proteolytic processing to become active:
IL-36β has a typical β-trefoil fold structure, which is a common feature among IL-1 family cytokines and is essential for its interaction with the IL-36 receptor and subsequent biological activity.
IL-36β is a member of the IL-36 subfamily within the IL-1 cytokine family. This subfamily includes:
These cytokines interact with the IL-36 receptor and play complementary roles in regulating inflammatory processes.
IL-36β has several important functions:
Dysregulation of IL-36β is linked to various inflammatory diseases:
Interleukin-36 beta (IL-36β) is a significant pro-inflammatory cytokine in the IL-1 family, involved in regulating inflammatory responses primarily in epithelial tissues. It acts through the IL-36 receptor, triggering pathways that lead to inflammation and immune cell activation. IL-36β is particularly relevant in skin diseases like psoriasis but also plays roles in inflammatory bowel disease, rheumatoid arthritis, and respiratory conditions. Understanding the mechanisms and effects of IL-36β is crucial for developing targeted therapies for these inflammatory diseases.
Interleukin-36 beta (IL36B)
IL1F8, IL-36β, IL36β,IL-36 beta,IL36 beta,IL-36b,IL36b,IL36B,IL-36B,IL-1F8
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, CLIA Kits, Primary Antibodies) relacionados con IL36B - Interleukin-36 beta
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 20 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | IL36B | EH2046 | Human IL36B(Interleukin-36 beta) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 31.25-2000pg/ml | 96T | Q9NZH7 | RUO | ||
Abbexa | IL36B | abx152010 | Human Interleukin 36 Beta (IL36B) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 7.8 pg/ml - 500 pg/ml | < 2.9 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | IL36B | abx190204 | Human Interleukin 36 Beta (IL36B) CLIA Kit | Human | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 1.37 pg/ml - 1000 pg/ml | < 0.51 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | IL36B | abx352844 | Mouse Interleukin 36 Beta (IL36B) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | 9.38 pg/ml | 587.5 | 96 tests | Q9NZH7 | RUO |
Abbexa | IL36B | abx496519 | Rat Interleukin 36 Beta (IL36B) CLIA Kit | Rat | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 7.8 pg/ml - 500 pg/ml | < 2.8 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | IL36B | abx353750 | Rat Interleukin 36 Beta (IL36B) ELISA Kit | Rat | Serum,Plasma,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | 9.38 pg/ml | 587.5 | 96 tests | RUO | |
Abbexa | IL36B | abx258919 | Rat Interleukin 36 Beta (IL36B) ELISA Kit | Rat | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 7.8 pg/ml - 500 pg/ml | < 2.8 pg/ml | 687.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | IL36B | FNab04241 | anti- IL1F8 antibody | human | monoclonal | Mouse | interleukin 1 family, member 8(eta) | IgG1 | Unconjugated | ELISA, WB, IHC | 100µg | Q9NZH7 | RUO | |
FineTest | IL36B | FNab04240 | anti- IL1F8 antibody | human | polyclonal | Rabbit | interleukin 1 family, member 8(eta) | IgG | Unconjugated | ELISA, WB | 100µg | Q9NZH7 | RUO | |
Abbexa | IL36B | abx234241 | Interleukin-1 Family Member 8 (IL1F8) Antibody | Human | Monoclonal | Mouse | Interleukin-1 Family Member 8 (IL1F8) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | Q9NZH7 | RUO | |
Abbexa | IL36B | abx323561 | Interleukin 36 Beta (IL36B) Antibody | Human | Polyclonal | Rabbit | Interleukin 36 Beta (IL36B) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q9NZH7 | RUO | |
Abbexa | IL36B | abx234240 | Interleukin-1 Family Member 8 (IL1F8) Antibody | Human | Polyclonal | Rabbit | Interleukin-1 Family Member 8 (IL1F8) | Unconjugated | ELISA, WB | 350 | 100 µg | Q9NZH7 | RUO | |
Abbexa | IL36B | abx375269 | Interleukin 36 Beta (IL36B) Antibody | Human | Polyclonal | Rabbit | Interleukin 36 Beta (IL36B) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | Q9NZH7 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | IL36B | abx653932 | Human Interleukin 36 Beta (IL36B) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 1800 | 1 mg | RUO | |
Abbexa | IL36B | abx262385 | IL36B 153 a.a. Protein | Human | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | Q9NZH7 | RUO | |
FineTest | IL36B | P6611 | Recombinant Mouse IL36 beta | Mouse | Recombinant | E.Coli | Western Blot,ELISA | 50μg | Q9D6Z6 | RUO | ||
Abbexa | IL36B | abx262954 | IL36B Protein | Mouse | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | Q9D6Z6 | RUO | |
Abbexa | IL36B | abx262951 | IL36B Protein | Human | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | Q9NZH7 | RUO | |
FineTest | IL36B | P6852 | Recombinant Human IL36 beta | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | Q9NZH7-2 | RUO | ||
Abbexa | IL36B | abx655703 | Human Interleukin 36 Beta (IL36B) Protein (Active) | Human | Recombinant | Unconjugated | WB, SDS-PAGE | 2725 | 1 mg | RUO |
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