anti- IL1F8 antibody

Este producto es parte de IL36B - Interleukin-36 beta
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935106861
info@markelab.com
name
anti- IL1F8 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab04240
tested applications
ELISA, WB

Documents del producto

Instrucciones
Descargar
Data sheet

Product specifications

Category
Primary Antibodies
Immunogen Target
interleukin 1 family, member 8(eta)
Host
Rabbit
Reactivity
human
Recommended Dilution
WB: 1:500-1:2000
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
44 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
Q9NZH7
Gene ID
27177
Alias
IL1F8, IL-36β, IL36β,IL-36 beta,IL36 beta,IL-36b,IL36b,IL36B,IL-36B,IL-1F8
Background
Antibody anti-IL36B
Status
RUO
Note
This product is for research use only.

IL36B is a pro-inflammatory cytokine of the IL-1 family that functions by signaling through the IL-36 receptor (IL1RL2) and its co-receptor IL1RAP. IL36B activates downstream NF-κB, MAPK, and JNK pathways, inducing the expression of pro-inflammatory cytokines, chemokines, and antimicrobial peptides. It is primarily expressed in epithelial cells, particularly in skin keratinocytes, and serves a key role in enhancing immune responses at epithelial barriers. IL36B promotes the recruitment and activation of immune cells such as dendritic cells, neutrophils, and T cells, amplifying inflammation in tissues exposed to pathogens or injury. It is a major driver of inflammatory processes in skin disorders, including psoriasis, where its overexpression leads to keratinocyte hyperproliferation and immune cell infiltration. IL36B is also involved in mucosal immunity within the lungs and gastrointestinal tract. Knockdown studies reveal impaired epithelial immunity, reduced inflammatory responses, and delayed wound healing, underscoring its role in amplifying innate immune responses, tissue defense, and inflammation regulation.

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