Interleukin-1 Family Member 8 (IL1F8) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Interleukin-1 Family Member 8 (IL1F8) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx234240
tested applications
ELISA, WB
Description
IL1F8 Antibody is a Rabbit Polyclonal against IL1F8.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Interleukin-1 Family Member 8 (IL1F8) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NZH7 |
| Alias | IL1F8, IL-36β, IL36β,IL-36 beta,IL36 beta,IL-36b,IL36b,IL36B,IL-36B,IL-1F8 |
| Background | Antibody anti-IL36B |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
IL36B is a pro-inflammatory cytokine of the IL-1 family that functions by signaling through the IL-36 receptor (IL1RL2) and its co-receptor IL1RAP. IL36B activates downstream NF-κB, MAPK, and JNK pathways, inducing the expression of pro-inflammatory cytokines, chemokines, and antimicrobial peptides. It is primarily expressed in epithelial cells, particularly in skin keratinocytes, and serves a key role in enhancing immune responses at epithelial barriers. IL36B promotes the recruitment and activation of immune cells such as dendritic cells, neutrophils, and T cells, amplifying inflammation in tissues exposed to pathogens or injury. It is a major driver of inflammatory processes in skin disorders, including psoriasis, where its overexpression leads to keratinocyte hyperproliferation and immune cell infiltration. IL36B is also involved in mucosal immunity within the lungs and gastrointestinal tract. Knockdown studies reveal impaired epithelial immunity, reduced inflammatory responses, and delayed wound healing, underscoring its role in amplifying innate immune responses, tissue defense, and inflammation regulation.
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