Family main features
Interleukin-10 (IL-10) is a cytokine, secreted by various immune cells such as T cells, B cells, macrophages, and dendritic cells. It is produced as a homodimer, meaning it consists of two identical subunits linked together. Each subunit contains about 160 amino acids and adopts a tertiary structure stabilized by disulfide bonds. IL-10 exerts its effects by binding to specific cell surface receptors, including the IL-10 receptor (IL-10R), which initiates downstream signaling pathways. IL-10 is primarily known for its anti-inflammatory properties. It suppresses the activity of pro-inflammatory cytokines and immune cells, thereby dampening the inflammatory response. IL-10 inhibits the production of cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6), and interferon-gamma (IFN-γ), which are involved in inflammation and immune activation. IL-10 plays a crucial role in regulating immune responses to pathogens and preventing excessive tissue damage caused by inflammation. It helps to maintain immune homeostasis by limiting the duration and intensity of immune responses, thereby preventing autoimmune reactions and tissue injury. IL-10 also promotes tissue repair and regeneration by reducing inflammation and promoting wound healing. It also contributes to the induction of immune tolerance, allowing the immune system to differentiate between harmless antigens and potential threats, thereby preventing autoimmune diseases. IL-10RA is a critical component of the IL-10 receptor complex, which also includes the IL-10 receptor subunit beta (IL-10RB).Upon ligand binding, IL-10 induces conformational changes in the IL-10 receptor complex, leading to the activation of intracellular signaling pathways. IL-10RB plays a crucial role in transmitting these signals, particularly through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway.
IL10RA is a type I transmembrane protein comprising 578 amino acids. The protein includes:
IL10RA is part of the class II cytokine receptor family, which includes receptors for various other cytokines like IL-22 and IL-26. IL10RA forms a receptor complex with IL-10 receptor beta (IL10RB), another subunit necessary for IL-10 signal transduction.
IL10RA (Interleukin 10 Receptor Alpha) is a vital receptor for the anti-inflammatory cytokine IL-10, playing a crucial role in immune regulation and the suppression of inflammation. By forming a receptor complex with IL10RB and activating the JAK-STAT signaling pathway, IL10RA mediates IL-10's effects, promoting immune homeostasis and preventing excessive inflammatory responses. Mutations or deficiencies in IL10RA are linked to various autoimmune and inflammatory diseases, highlighting its significance in health and disease. Understanding IL10RA's function and interactions provides valuable insights for developing therapeutic strategies to modulate immune responses and treat related disorders.
Interleukin 10 Receptor Alpha (IL10RA)
CD210,Interleukin-10 receptor subunit 1,IL-10R subunit 1,IL-10R1)
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, CLIA Kits, Primary Antibodies, ELISA Kits) relacionados con IL10RA - Interleukin 10 Receptor Alpha
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Esta página contiene 33 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | IL10RA | abx492922 | Human Interleukin 10 Receptor Alpha (IL10Ra) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 31.25 pg/ml - 2000 pg/ml | < 11.3 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | IL10RA | abx595311 | IL-10Ralpha Cell ELISA Kit | Human | Cell ELISA | 493.75 | 96 tests | Q13651 | RUO | |||
Abbexa | IL10RA | abx151923 | Human Interleukin 10 Receptor Alpha (IL10Ra) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | < 11.3 pg/ml | 662.5 | 96 tests | Q13651 | RUO |
Abbexa | IL10RA | abx154188 | Mouse Interleukin 10 Receptor Alpha (IL10Ra) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 29 pg/ml | 675 | 96 tests | RUO | |
Abbexa | IL10RA | abx492923 | Mouse Interleukin 10 Receptor Alpha (IL10Ra) CLIA Kit | Mouse | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 78.12 pg/ml - 5000 pg/ml | < 27 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | IL10RA | abx155676 | Rat Interleukin 10 Receptor Alpha (IL10Ra) ELISA Kit | Rat | Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | IL10RA | abx492924 | Rat Interleukin 10 Receptor Alpha (IL10Ra) CLIA Kit | Rat | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.063 ng/ml | 812.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
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FineTest | IL10RA | FNab04213 | anti- IL10RA antibody | human | polyclonal | Rabbit | interleukin 10 receptor, alpha | IgG | Unconjugated | ELISA, WB, IHC, IF | 100µg | Q13651 | RUO | |
Abbexa | IL10RA | abx323395 | Interleukin 10 Receptor Alpha (IL10RA) Antibody | Human | Polyclonal | Rabbit | Interleukin 10 Receptor Alpha (IL10RA) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q13651 | RUO | |
Abbexa | IL10RA | abx034094 | Interleukin 10 Receptor Alpha (IL10RA) Antibody | Human | Polyclonal | Rabbit | Interleukin 10 Receptor Alpha (IL10RA) | Unconjugated | ELISA, WB, IF/ICC, FCM | 281.25 | 80 µl | Q13651 | RUO | |
Abbexa | IL10RA | abx103276 | Interleukin 10 Receptor Alpha (IL10Ra) Antibody | Human | Polyclonal | Rabbit | Interleukin 10 Receptor Alpha (IL10Ra) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q13651 | RUO | |
Abbexa | IL10RA | abx113232 | Interleukin 10 Receptor Alpha (IL10RA) Antibody | Human | Polyclonal | Rabbit | Interleukin 10 Receptor Alpha (IL10RA) | Unconjugated | ELISA, WB | 612.5 | 100 µl | Q13651 | RUO | |
Abbexa | IL10RA | abx317387 | Interleukin 10 Receptor Alpha (IL10RA) Antibody (FITC) | Human | Polyclonal | Rabbit | Interleukin 10 Receptor Alpha (IL10RA) | FITC | 162.5 | 20 µg | Q13651 | RUO | ||
Abbexa | IL10RA | abx317388 | Interleukin 10 Receptor Alpha (IL10RA) Antibody (Biotin) | Human | Polyclonal | Rabbit | Interleukin 10 Receptor Alpha (IL10RA) | Biotin | ELISA | 162.5 | 20 µg | Q13651 | RUO | |
Abbexa | IL10RA | abx339847 | Interleukin 10 Receptor Alpha (IL10RA) Antibody | Human | Polyclonal | Rabbit | Interleukin 10 Receptor Alpha (IL10RA) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q13651 | RUO | |
Abbexa | IL10RA | abx339078 | Interleukin 10 Receptor Alpha (IL10RA) Antibody | Human | Polyclonal | Rabbit | Interleukin 10 Receptor Alpha (IL10RA) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q13651 | RUO | |
Abbexa | IL10RA | abx323517 | Interleukin 10 Receptor Alpha Phospho-Tyr496 (IL10RA pY496) Antibody | Human | Polyclonal | Rabbit | Interleukin 10 Receptor Alpha Phospho-Tyr496 (IL10RA pY496) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q13651 | RUO | |
Abbexa | IL10RA | abx332916 | Interleukin 10 Receptor Alpha Phospho-Ser319/323 (IL10RA pS319/323) Antibody | Human | Polyclonal | Rabbit | Interleukin 10 Receptor Alpha Phospho-Ser319/323 (IL10RA pS319/323) | Unconjugated | ELISA, WB | 412.5 | 100 µl | Q13651 | RUO | |
Abbexa | IL10RA | abx332947 | IL10RA (pY496) Antibody | Human | Polyclonal | Rabbit | IL10RA (pY496) | Unconjugated | ELISA, WB | 412.5 | 100 µl | Q13651 | RUO | |
Abbexa | IL10RA | abx317386 | Interleukin 10 Receptor Alpha (IL10RA) Antibody (HRP) | Human | Polyclonal | Rabbit | Interleukin 10 Receptor Alpha (IL10RA) | HRP | ELISA | 162.5 | 20 µg | Q13651 | RUO | |
Abbexa | IL10RA | abx173058 | Interleukin 10 Receptor Alpha (IL10Ra) Antibody | Human | Monoclonal | Mouse | Interleukin 10 Receptor Alpha (IL10Ra) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | IL10RA | abx272168 | Interleukin 10 Receptor Alpha (IL10Ra) Antibody (Biotin) | Human | Polyclonal | Rabbit | Interleukin 10 Receptor Alpha (IL10Ra) | Biotin | WB, IHC, IF/ICC | 350 | 200 µl | RUO | ||
Abbexa | IL10RA | abx301107 | Interleukin 10 Receptor Alpha (IL10RA) Antibody | Human | Polyclonal | Rabbit | Interleukin 10 Receptor Alpha (IL10RA) | Unconjugated | ELISA, WB, IF/ICC | 162.5 | 20 µg | Q13651 | RUO | |
Abbexa | IL10RA | abx324099 | Interleukin 10 Receptor Alpha (IL10RA) Antibody | Human | Polyclonal | Rabbit | Interleukin 10 Receptor Alpha (IL10RA) | Unconjugated | ELISA, WB, IF/ICC | 187.5 | 50 µg | Q13651 | RUO | |
Abbexa | IL10RA | abx322149 | Interleukin 10 Receptor Alpha (IL10RA) Antibody | Human | Polyclonal | Rabbit | Interleukin 10 Receptor Alpha (IL10RA) | Unconjugated | ELISA, WB, IHC | 237.5 | 50 µl | Q13651 | RUO | |
Abbexa | IL10RA | abx234213 | Interleukin 10 Receptor Alpha (IL10RA) Antibody | Human | Polyclonal | Rabbit | Interleukin 10 Receptor Alpha (IL10RA) | Unconjugated | ELISA, WB, IHC, IF/ICC | 350 | 100 µg | Q13651 | RUO | |
Abbexa | IL10RA | abx001512 | Interleukin 10 Receptor Alpha (IL10RA) Antibody | Human | Polyclonal | Rabbit | Interleukin 10 Receptor Alpha (IL10RA) | Unconjugated | WB, IHC, IF/ICC | 175 | 20 µl | Q13651 | RUO | |
Abbexa | IL10RA | abx103277 | Interleukin 10 Receptor Alpha (IL10Ra) Antibody | Mouse | Polyclonal | Rabbit | Interleukin 10 Receptor Alpha (IL10Ra) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q61727 | RUO | |
Abbexa | IL10RA | abx173059 | Interleukin 10 Receptor Alpha (IL10Ra) Antibody | Mouse | Monoclonal | Mouse | Interleukin 10 Receptor Alpha (IL10Ra) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | IL10RA | abx653949 | Mouse Interleukin 10 Receptor Alpha (IL10Ra) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | RUO | |
Abbexa | IL10RA | abx067426 | Human Interleukin 10 Receptor Alpha (IL10Ra) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | Q13651 | RUO |
Abbexa | IL10RA | abx653950 | Rat Interleukin 10 Receptor Alpha (IL10Ra) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 1800 | 1 mg | RUO | |
Abbexa | IL10RA | abx067427 | Mouse Interleukin 10 Receptor Alpha (IL10Ra) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 250 | 10 µg | Q61727 | RUO |
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