Mouse Interleukin 10 Receptor Alpha (IL10Ra) Protein
260€ (10 µg)
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Name
Mouse Interleukin 10 Receptor Alpha (IL10Ra) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx067427
Tested Applications
WB, SDS-PAGE
Description
Mouse Interleukin 10 Receptor Alpha (IL10Ra) is a recombinant Mouse protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin 10 Receptor Alpha (IL10Ra) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Leu17-Ile241 Tag: N-terminal His tag and GST tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 56.3 kDa Observed MW (SDS-PAGE): 57 kDa |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q61727 |
| Alias | CD210,Interleukin-10 receptor subunit 1,IL-10R subunit 1,IL-10R1 |
| Background | Protein IL10RA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in ddH2O to a concentration between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
IL10RA is a critical component of the interleukin-10 (IL10) receptor complex, primarily expressed on immune cells like monocytes, macrophages, dendritic cells, and T cells This receptor binds IL10, a potent anti-inflammatory cytokine, and works in conjunction with IL10 receptor beta (IL10RB) to mediate downstream signaling through the JAK1/STAT3 pathway IL10RA contains an extracellular domain that facilitates IL10 binding, a transmembrane region, and an intracellular segment that interacts with JAK1 kinase Activation of IL10RA suppresses pro-inflammatory cytokines, including TNF-α, IL6, and IL12, while enhancing immune tolerance and promoting tissue homeostasis Loss-of-function mutations in IL10RA disrupt IL10 signaling, leading to early-onset inflammatory bowel disease (IBD) and other severe inflammatory conditions, often in childhood IL10RA dysfunction results in an inability to regulate immune responses effectively, leading to hyperactivation of inflammatory pathways Therapies targeting IL10RA, such as recombinant IL10 or receptor-modulating agents, are being investigated for autoimmune diseases and inflammatory disorders due to their ability to restore IL10-mediated anti-inflammatory signaling IL10RA also plays a role in tumor progression by suppressing immune activation in the tumor microenvironment, making it a potential immunotherapy target
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