IL-10Ralpha Cell ELISA Kit
513.5€ (96 tests)
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Name
IL-10Ralpha Cell ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx595311
Tested Applications
ELISA
Description
IL-10Ralpha Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Immunogen Target | IL-10Ralpha |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q13651 |
| Gene ID | 3587 |
| OMIM | 146933 |
| Alias | CD210,Interleukin-10 receptor subunit 1,IL-10R subunit 1,IL-10R1 |
| Background | Elisa Kits for: IL10RA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Background
IL10RA is a critical component of the interleukin-10 (IL10) receptor complex, primarily expressed on immune cells like monocytes, macrophages, dendritic cells, and T cells This receptor binds IL10, a potent anti-inflammatory cytokine, and works in conjunction with IL10 receptor beta (IL10RB) to mediate downstream signaling through the JAK1/STAT3 pathway IL10RA contains an extracellular domain that facilitates IL10 binding, a transmembrane region, and an intracellular segment that interacts with JAK1 kinase Activation of IL10RA suppresses pro-inflammatory cytokines, including TNF-α, IL6, and IL12, while enhancing immune tolerance and promoting tissue homeostasis Loss-of-function mutations in IL10RA disrupt IL10 signaling, leading to early-onset inflammatory bowel disease (IBD) and other severe inflammatory conditions, often in childhood IL10RA dysfunction results in an inability to regulate immune responses effectively, leading to hyperactivation of inflammatory pathways Therapies targeting IL10RA, such as recombinant IL10 or receptor-modulating agents, are being investigated for autoimmune diseases and inflammatory disorders due to their ability to restore IL10-mediated anti-inflammatory signaling IL10RA also plays a role in tumor progression by suppressing immune activation in the tumor microenvironment, making it a potential immunotherapy target
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