Human Interleukin 10 Receptor Alpha (IL10Ra) Protein
247€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Human Interleukin 10 Receptor Alpha (IL10Ra) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx067426
Tested Applications
WB, SDS-PAGE
Description
Human Interleukin 10 Receptor Alpha (IL10Ra) is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin 10 Receptor Alpha (IL10Ra) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Leu132-Asn235 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 13.2 kDa Observed MW (SDS-PAGE): 14 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13651 |
| Alias | CD210,Interleukin-10 receptor subunit 1,IL-10R subunit 1,IL-10R1 |
| Background | Protein IL10RA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
IL10RA is a critical component of the interleukin-10 (IL10) receptor complex, primarily expressed on immune cells like monocytes, macrophages, dendritic cells, and T cells This receptor binds IL10, a potent anti-inflammatory cytokine, and works in conjunction with IL10 receptor beta (IL10RB) to mediate downstream signaling through the JAK1/STAT3 pathway IL10RA contains an extracellular domain that facilitates IL10 binding, a transmembrane region, and an intracellular segment that interacts with JAK1 kinase Activation of IL10RA suppresses pro-inflammatory cytokines, including TNF-α, IL6, and IL12, while enhancing immune tolerance and promoting tissue homeostasis Loss-of-function mutations in IL10RA disrupt IL10 signaling, leading to early-onset inflammatory bowel disease (IBD) and other severe inflammatory conditions, often in childhood IL10RA dysfunction results in an inability to regulate immune responses effectively, leading to hyperactivation of inflammatory pathways Therapies targeting IL10RA, such as recombinant IL10 or receptor-modulating agents, are being investigated for autoimmune diseases and inflammatory disorders due to their ability to restore IL10-mediated anti-inflammatory signaling IL10RA also plays a role in tumor progression by suppressing immune activation in the tumor microenvironment, making it a potential immunotherapy target
Productos relacionados
Interleukin 10 Receptor Alpha (IL10RA) Antibody
IL10RA Antibody is a Rabbit Polyclonal antibody against IL10RA. The protein encoded by this gene is a receptor for inter…
Ver producto
Interleukin 10 Receptor Alpha (IL10RA) Antibody
IL10RA is a receptor for IL10; binds IL10 with a high affinity.…
Ver producto Human Interleukin 10 Receptor Alpha (IL10Ra) Protein
Human Interleukin 10 Receptor Alpha (IL10Ra) is a recombinant Human protein expressed in E. coli.…
Ver producto