Interleukin 10 Receptor Alpha Phospho-Tyr496 (IL10RA pY496) Antibody
221€ (50 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Interleukin 10 Receptor Alpha Phospho-Tyr496 (IL10RA pY496) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx323517
Tested Applications
ELISA, WB
Description
IL10RA (pY496) Antibody is a Rabbit Polyclonal against IL10RA (pY496).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Interleukin 10 Receptor Alpha Phospho-Tyr496 (IL10RA pY496) Immunogen: Synthesized peptide derived from human IL-10Rα around the phosphorylation site of Y496. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | ELISA: 1/20000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13651 |
| Gene ID | 3587 |
| Alias | CD210,Interleukin-10 receptor subunit 1,IL-10R subunit 1,IL-10R1 |
| Background | Antibody anti-IL10RA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
IL10RA is a critical component of the interleukin-10 (IL10) receptor complex, primarily expressed on immune cells like monocytes, macrophages, dendritic cells, and T cells This receptor binds IL10, a potent anti-inflammatory cytokine, and works in conjunction with IL10 receptor beta (IL10RB) to mediate downstream signaling through the JAK1/STAT3 pathway IL10RA contains an extracellular domain that facilitates IL10 binding, a transmembrane region, and an intracellular segment that interacts with JAK1 kinase Activation of IL10RA suppresses pro-inflammatory cytokines, including TNF-α, IL6, and IL12, while enhancing immune tolerance and promoting tissue homeostasis Loss-of-function mutations in IL10RA disrupt IL10 signaling, leading to early-onset inflammatory bowel disease (IBD) and other severe inflammatory conditions, often in childhood IL10RA dysfunction results in an inability to regulate immune responses effectively, leading to hyperactivation of inflammatory pathways Therapies targeting IL10RA, such as recombinant IL10 or receptor-modulating agents, are being investigated for autoimmune diseases and inflammatory disorders due to their ability to restore IL10-mediated anti-inflammatory signaling IL10RA also plays a role in tumor progression by suppressing immune activation in the tumor microenvironment, making it a potential immunotherapy target
Productos relacionados
Interleukin 10 Receptor Alpha (IL10RA) Antibody
IL10RA Antibody is a Rabbit Polyclonal antibody against IL10RA. The protein encoded by this gene is a receptor for inter…
Ver producto
Interleukin 10 Receptor Alpha (IL10RA) Antibody
IL10RA is a receptor for IL10; binds IL10 with a high affinity.…
Ver producto
Human Interleukin 10 Receptor Alpha (IL10Ra) Protein
Human Interleukin 10 Receptor Alpha (IL10Ra) is a recombinant Human protein expressed in E. coli.…
Ver producto