Family main features
CRKL (Crk-like protein) is an adaptor protein that plays a crucial role in intracellular signal transduction pathways. It is a member of the CRK family of adaptor proteins, which also includes CRK. CRKL is involved in various cellular processes, including cell growth, adhesion, migration, and differentiation. It functions primarily by linking receptor tyrosine kinases (RTKs) and other signaling proteins to downstream effectors, facilitating the assembly of multi-protein signaling complexes. CRKL is widely expressed in different tissues, with particularly high expression levels in hematopoietic cells. Its involvement in multiple signaling pathways underscores its importance in both normal cellular functions and disease processes.
CRKL’s structure is characterized by specific domains that facilitate its role as an adaptor protein:
CRKL is classified as an adaptor protein within the CRK family, which includes:
CRKL is involved in multiple critical cellular functions:
Alterations in CRKL function or expression are associated with several diseases:
CRKL is a multifunctional adaptor protein essential for various signal transduction pathways that regulate cell growth, adhesion, migration, and differentiation. Its structure includes an SH2 domain and two SH3 domains, enabling it to mediate interactions between phosphorylated proteins and other signaling molecules. By assembling signaling complexes, CRKL propagates intracellular signals crucial for numerous cellular functions. Dysregulation of CRKL is associated with diseases such as cancer, CML, developmental disorders, and fibrosis. Understanding CRKL's role in these processes is vital for developing therapeutic strategies targeting its signaling pathways in various diseases.
Crk-like protein (CRKL)
CRK like proto-oncogene, crk-like protein
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits, CLIA Kits) relacionados con CRKL-Crk-like protein
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 28 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CRKL | abx151185 | Human Crk Like Protein (CRKL) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | CRKL | abx495286 | Human Crk Like Protein (CRKL) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.058 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | CRKL | abx595150 | Crk-Like Protein (CRKL) Cell ELISA Kit | Human | Cell ELISA | 493.75 | 96 tests | P46109 | RUO | |||
Abbexa | CRKL | abx595987 | CrkL (pY207) Cell ELISA Kit | Human | Cell ELISA | 525 | 2 × 96 tests | P46109 | RUO | |||
Abbexa | CRKL | abx153873 | Mouse Crk Like Protein (CRKL) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 33 pg/ml | 687.5 | 96 tests | RUO | |
Abbexa | CRKL | abx495287 | Mouse Crk Like Protein (CRKL) CLIA Kit | Mouse | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 78.12 pg/ml - 5000 pg/ml | < 33 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | CRKL | abx392108 | Rat Crk-Like Protein (CRKL) ELISA Kit | Rat | Serum,Plasma,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | Q5U2U2 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CRKL | abx104998 | Crk Like Protein (CRKL) Antibody | Human | Polyclonal | Rabbit | Crk Like Protein (CRKL) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | P46109 | RUO | |
Abbexa | CRKL | abx171950 | Crk Like Protein (CRKL) Antibody | Human | Monoclonal | Mouse | Crk Like Protein (CRKL) | Unconjugated | WB, IHC, IF/ICC | 787.5 | 1 ml | RUO | ||
Abbexa | CRKL | abx012058 | Crk-Like Protein (CRKL) Antibody | Human | Monoclonal | Mouse | Crk-Like Protein (CRKL) | Unconjugated | ELISA, FCM | 362.5 | 100 µl | P46109 | RUO | |
Abbexa | CRKL | abx314805 | Crk-Like Protein (CRKL) Antibody (FITC) | Human | Polyclonal | Rabbit | Crk-Like Protein (CRKL) | FITC | 162.5 | 20 µg | P46109 | RUO | ||
Abbexa | CRKL | abx027457 | Crk-Like Protein (CRKL) Antibody | Human | Polyclonal | Rabbit | Crk-Like Protein (CRKL) | Unconjugated | ELISA, WB | 250 | 80 µl | P46109 | RUO | |
Abbexa | CRKL | abx314804 | Crk-Like Protein (CRKL) Antibody (HRP) | Human | Polyclonal | Rabbit | Crk-Like Protein (CRKL) | HRP | ELISA | 162.5 | 20 µg | P46109 | RUO | |
Abbexa | CRKL | abx314806 | Crk-Like Protein (CRKL) Antibody (Biotin) | Human | Polyclonal | Rabbit | Crk-Like Protein (CRKL) | Biotin | ELISA | 162.5 | 20 µg | P46109 | RUO | |
Abbexa | CRKL | abx302470 | Crk-Like Protein (CRKL) Antibody | Human | Polyclonal | Rabbit | Crk-Like Protein (CRKL) | Unconjugated | ELISA, WB, IF/ICC | 162.5 | 20 µg | P46109 | RUO | |
Abbexa | CRKL | abx432554 | Crk Like Protein (CRKL) Antibody | Human | Polyclonal | Goat | Crk Like Protein (CRKL) | Unconjugated | P-ELISA, WB, IHC | 387.5 | 200 µl | RUO | ||
Abbexa | CRKL | abx007367 | Crk Like Protein (CRKL) Antibody | Human | Polyclonal | Rabbit | Crk Like Protein (CRKL) | Unconjugated | WB | 175 | 20 µl | P46109 | RUO | |
Abbexa | CRKL | abx241959 | Crk-Like Protein (CRKL) Antibody | Human | Polyclonal | Rabbit | Crk-Like Protein (CRKL) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | P46109 | RUO | |
Abbexa | CRKL | abx125721 | Crk-Like Protein (CRKL) Antibody | Human | Polyclonal | Rabbit | Crk-Like Protein (CRKL) | Unconjugated | WB | 175 | 20 µl | P46109 | RUO | |
Abbexa | CRKL | abx241958 | Crk-Like Protein (CRKL) Antibody | Human | Polyclonal | Rabbit | Crk-Like Protein (CRKL) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | P46109 | RUO | |
Abbexa | CRKL | abx330087 | Crk Like Protein Phospho-Tyr207 (CRKL pY207) Antibody | Human | Polyclonal | Rabbit | Crk Like Protein Phospho-Tyr207 (CRKL pY207) | Unconjugated | ELISA, WB, IHC, IF/ICC | 187.5 | 50 µg | P46109 | RUO | |
Abbexa | CRKL | abx330030 | Crk-Like Protein (CRKL) Antibody | Human | Polyclonal | Rabbit | Crk-Like Protein (CRKL) | Unconjugated | ELISA, WB, IHC, IF/ICC | 187.5 | 50 µg | P46109 | RUO | |
Abbexa | CRKL | abx030947 | Crk-Like Protein (CRKL) Antibody | Mouse | Polyclonal | Rabbit | Crk-Like Protein (CRKL) | Unconjugated | ELISA, WB | 281.25 | 80 µl | P47941 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | CRKL | P5217 | Recombinant Human CrkL | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | P46109 | RUO | ||
FineTest | CRKL | P0259 | Recombinant Human CRKIL | Human | Recombinant | E.Coli | Western Blot, ELISA | 50μg | P46108 | RUO | ||
Abbexa | CRKL | abx165877 | Human Crk Like Protein (CRKL) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | P46109 | RUO |
Abbexa | CRKL | abx260833 | Crk-Like Protein (CRKL) Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 5 µg | P46109 | RUO | ||
Abbexa | CRKL | abx653073 | Mouse Crk Like Protein (CRKL) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 1800 | 1 mg | RUO |
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