Crk-Like Protein (CRKL) Antibody
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Description
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Crk-Like Protein (CRKL) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, FCM |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P46109 |
| Gene ID | 1399 |
| OMIM | 602007 |
| Alias | CRK like proto-oncogene, crk-like protein |
| Background | Antibody anti-CRKL |
| Status | RUO |
| Note | Concentration: Not determined. - |
Descripción
Crk-like protein (CRKL) is another adaptor protein that is structurally similar to CRK but has its own unique functions in cellular signaling. Like CRK, CRKL contains SH2 and SH3 domains, enabling it to interact with a variety of signaling molecules involved in cellular growth, survival, and migration. CRKL is a key component of signaling pathways activated by various RTKs, including those involved in cell differentiation and cytoskeletal remodeling. It plays an important role in cellular responses to growth factors, such as epidermal growth factor (EGF), and is implicated in the regulation of immune cell function. Dysregulation of CRKL has been linked to certain cancers and other diseases where altered cellular signaling occurs.
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Crk-Like Protein (CRKL) Antibody
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
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Crk-Like Protein (CRKL) Antibody
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
Ver Producto