Mouse Crk Like Protein (CRKL) Protein
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Description
Mouse Crk Like Protein (CRKL) Protein is a Recombinant Mouse protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Crk Like Protein (CRKL) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Please enquire. Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | CRK like proto-oncogene, crk-like protein |
| Background | Protein CRKL |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Crk-like protein (CRKL) is another adaptor protein that is structurally similar to CRK but has its own unique functions in cellular signaling. Like CRK, CRKL contains SH2 and SH3 domains, enabling it to interact with a variety of signaling molecules involved in cellular growth, survival, and migration. CRKL is a key component of signaling pathways activated by various RTKs, including those involved in cell differentiation and cytoskeletal remodeling. It plays an important role in cellular responses to growth factors, such as epidermal growth factor (EGF), and is implicated in the regulation of immune cell function. Dysregulation of CRKL has been linked to certain cancers and other diseases where altered cellular signaling occurs.
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