Family main features
TNF receptor superfamily member 21 (TNFRSF21), also known as death receptor 6 (DR6), is a member of the tumor necrosis factor receptor (TNFR) superfamily. Like other TNFR members, TNFRSF21 is involved in processes that modulate immune responses, cell death, and survival pathways. This receptor is particularly involved in apoptosis, immune cell regulation, and central nervous system functions. TNFRSF21/DR6 is expressed in a range of tissues but is predominantly found in lymphoid organs, nervous system cells, and tissues associated with inflammatory processes.
TNFRSF21 plays a significant role in neuroinflammation and neurodegeneration, as well as in the regulation of immune responses. It is a type I transmembrane protein that acts as a receptor for ligands like tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and amyloid precursor protein (APP)-derived peptides. Due to its involvement in cell apoptosis, particularly in neural cells, TNFRSF21 has garnered interest for its potential therapeutic applications in neurodegenerative diseases such as Alzheimer’s disease. Additionally, its function in immune cell regulation places it as a candidate target in autoimmune diseases and certain cancers.
TNFRSF21/DR6 is a type I transmembrane glycoprotein composed of approximately 655 amino acids, with several distinct structural regions:
Extracellular Domain:
Transmembrane Domain:
Intracellular Death Domain:
TNFRSF21/DR6 belongs to the broader TNFR superfamily, which includes various receptors that play roles in immune response modulation, cell survival, apoptosis, and inflammation. Within the TNFR superfamily, TNFRSF21 is categorized as a “death receptor” due to its death domain, which confers pro-apoptotic capabilities. Other receptors in this subgroup include TNFR1, Fas/CD95, and TRAIL receptors.
Although TNFRSF21 itself does not have distinct isoforms or subtypes, its functional complexity arises from its interactions with various ligands, adaptors, and intracellular signaling molecules. The TNFRSF21 gene expression can be regulated by cellular context and inflammatory stimuli, affecting the receptor's functional roles across different tissues.
TNFRSF21/DR6 plays multifaceted roles, from mediating cell death to modulating immune responses and neurodevelopment. Key functional aspects include:
Apoptosis and Cell Death:
Immune Cell Regulation:
Role in Nervous System Development and Neurodegeneration:
Inflammatory Response:
Autoimmune Diseases:
Neurodegenerative Diseases:
Cancer:
Infectious Diseases:
TNFRSF21, or DR6, is a member of the TNF receptor superfamily that plays critical roles in apoptosis, immune cell regulation, and inflammatory responses. Structurally, it is composed of an extracellular domain with four cysteine-rich motifs, a transmembrane domain, and an intracellular death domain that facilitates apoptosis through adaptor interactions. Functionally, TNFRSF21 regulates immune responses by modulating T and B cell survival and is essential in apoptotic pathways in both immune and neural cells.
TNFRSF21’s involvement in immune cell apoptosis underpins its role in autoimmune diseases, where excessive activation can lead to chronic inflammation. In the nervous system, its activation by amyloid precursor protein fragments links it to neurodegenerative conditions such as Alzheimer’s disease. Additionally, TNFRSF21 is relevant to cancer biology, where its modulation may affect immune surveillance within tumors.
Therapeutically, targeting TNFRSF21 is an area of interest, as modulating its activity may offer benefits in treating autoimmune disorders, neurodegenerative diseases, and cancers where its function contributes to disease progression.
TNF receptor superfamily member 21 (TNFRSF21)
Tumor necrosis factor receptor superfamily member 21,DR6,CD358,BM-018,Death receptor 6
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Esta página contiene 23 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | TNFRSF21 | EH4485 | Human TNFRSF21(Tumor necrosis factor receptor superfamily member 21) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 15.625-1000pg/ml | 96T | O75509 | RUO | ||
Abbexa | TNFRSF21 | abx550723 | Human Tumor necrosis factor receptor superfamily member 21 (TNFRSF21) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | O75509 | RUO | ||
Abbexa | TNFRSF21 | abx550724 | Mouse Tumor necrosis factor receptor superfamily member 21 (TNFRSF21) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9EPU5 | RUO | ||
Abbexa | TNFRSF21 | abx550725 | Rat Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | D3ZF92 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
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Abbexa | TNFRSF21 | abx029423 | Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Antibody | Human | Polyclonal | Rabbit | Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) | Unconjugated | ELISA, WB | 250 | 80 µl | O75509 | RUO | |
Abbexa | TNFRSF21 | abx272501 | Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Antibody (Biotin) | Human | Polyclonal | Rabbit | Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) | Biotin | WB, IHC, IF/ICC | 362.5 | 200 µl | RUO | ||
Abbexa | TNFRSF21 | abx104675 | Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Antibody | Human | Polyclonal | Rabbit | Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | TNFRSF21 | abx321506 | Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Antibody | Human | Polyclonal | Rabbit | Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) | Unconjugated | ELISA, WB, IHC | 237.5 | 50 µl | O75509 | RUO | |
Abbexa | TNFRSF21 | abx339097 | Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Antibody | Human | Polyclonal | Rabbit | Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) | Unconjugated | ELISA, WB | 250 | 50 µl | O75509 | RUO | |
Abbexa | TNFRSF21 | abx038021 | Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Antibody | Human | Polyclonal | Rabbit | Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | TNFRSF21 | abx213800 | Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Antibody | Human | Polyclonal | Rabbit | Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) | Unconjugated | ELISA, IHC | 250 | 50 µl | O75509 | RUO | |
Abbexa | TNFRSF21 | abx006930 | Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Antibody | Human | Polyclonal | Rabbit | Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) | Unconjugated | WB | 175 | 20 µl | O75509 | RUO | |
Abbexa | TNFRSF21 | abx272972 | Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Antibody (Biotin) | Mouse | Polyclonal | Rabbit | Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) | Biotin | WB, IHC, IF/ICC | 375 | 200 µl | RUO | ||
Abbexa | TNFRSF21 | abx104676 | Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Antibody | Mouse | Polyclonal | Rabbit | Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | TNFRSF21 | abx693666 | Human Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 1050 | 100 µg | RUO | ||
Abbexa | TNFRSF21 | abx692006 | Mouse Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 100 µg | RUO | ||
Abbexa | TNFRSF21 | abx691011 | Human Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 587.5 | 100 µg | RUO | ||
Abbexa | TNFRSF21 | abx690077 | Mouse Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Protein | Mouse | Recombinant | Human | SDS-PAGE | 225 | 10 µg | RUO | ||
Abbexa | TNFRSF21 | abx691071 | Human Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Protein | Human | Recombinant | Human | SDS-PAGE | 175 | 10 µg | O75509 | RUO | |
Abbexa | TNFRSF21 | abx069568 | Mouse Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Protein | Mouse | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q9EPU5 | RUO | |
Abbexa | TNFRSF21 | abx690078 | Human Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Protein | Human | Recombinant | Human | SDS-PAGE | 150 | 10 µg | RUO | ||
Abbexa | TNFRSF21 | abx692005 | Human Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 912.5 | 100 µg | RUO | ||
Abbexa | TNFRSF21 | abx069569 | Human Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Protein | Human | E. coli | Unconjugated | WB, SDS-PAGE | 2275 | 1 mg | O75509 | RUO |
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