Human Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Protein (Active)
819€ (100 µg)
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935106861
info@markelab.com
name
Human Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx691011
tested applications
SDS-PAGE
Description
Human DR6 Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the extracellular domain (Met 1-Leu 350) of human DR6 (NP_055267.1) precursor was expressed with the fused Fc region of human IgG1 at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | DR6 |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: 60.3 kDa Sequence Fragment: Met1-Leu350 Tag: C-terminal Fc tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_055267.1 |
| Alias | Tumor necrosis factor receptor superfamily member 21,DR6,CD358,BM-018,Death receptor 6 |
| Background | Protein TNFRSF21 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
TNF receptor superfamily member 21 (TNFRSF21), also known as death receptor 6 (DR6), is a member of the tumor necrosis factor receptor (TNFR) superfamily. Like other TNFR members, TNFRSF21 is involved in processes that modulate immune responses, cell death, and survival pathways. This receptor is particularly involved in apoptosis, immune cell regulation, and central nervous system functions. TNFRSF21/DR6 is expressed in a range of tissues but is predominantly found in lymphoid organs, nervous system cells, and tissues associated with inflammatory processes. TNFRSF21 plays a significant role in neuroinflammation and neurodegeneration, as well as in the regulation of immune responses. It is a type I transmembrane protein that acts as a receptor for ligands like tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and amyloid precursor protein (APP)-derived peptides. Due to its involvement in cell apoptosis, particularly in neural cells, TNFRSF21 has garnered interest for its potential therapeutic applications in neurodegenerative diseases such as Alzheimer’s disease. Additionally, its function in immune cell regulation places it as a candidate target in autoimmune diseases and certain cancers.
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