Mouse Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein TNFRSF21
proveedor
Abbexareference
abx069568Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Background
TNF receptor superfamily member 21 (TNFRSF21), also known as death receptor 6 (DR6), is a member of the tumor necrosis factor receptor (TNFR) superfamily. Like other TNFR members, TNFRSF21 is involved in processes that modulate immune responses, cell death, and survival pathways. This receptor is particularly involved in apoptosis, immune cell regulation, and central nervous system functions. TNFRSF21/DR6 is expressed in a range of tissues but is predominantly found in lymphoid organs, nervous system cells, and tissues associated with inflammatory processes. TNFRSF21 plays a significant role in neuroinflammation and neurodegeneration, as well as in the regulation of immune responses. It is a type I transmembrane protein that acts as a receptor for ligands like tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and amyloid precursor protein (APP)-derived peptides. Due to its involvement in cell apoptosis, particularly in neural cells, TNFRSF21 has garnered interest for its potential therapeutic applications in neurodegenerative diseases such as Alzheimer’s disease. Additionally, its function in immune cell regulation places it as a candidate target in autoimmune diseases and certain cancers.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 23.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys406-His605 Tag: N-terminal His tag
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
TNFRSF21
dry ice
No
availability
Shipped within 5-12 working days.
alias
Tumor necrosis factor receptor superfamily member 21,DR6,CD358,BM-018,Death receptor 6
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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