Human Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Protein

Este producto es parte de TNFRSF21 - TNF receptor superfamily member 21
Human Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Protein

Pida mas información

935106861

info@markelab.com

Precio

2366€ (1 mg)

Protein TNFRSF21

proveedor

Abbexa

reference

abx069569

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

TNF receptor superfamily member 21 (TNFRSF21), also known as death receptor 6 (DR6), is a member of the tumor necrosis factor receptor (TNFR) superfamily. Like other TNFR members, TNFRSF21 is involved in processes that modulate immune responses, cell death, and survival pathways. This receptor is particularly involved in apoptosis, immune cell regulation, and central nervous system functions. TNFRSF21/DR6 is expressed in a range of tissues but is predominantly found in lymphoid organs, nervous system cells, and tissues associated with inflammatory processes. TNFRSF21 plays a significant role in neuroinflammation and neurodegeneration, as well as in the regulation of immune responses. It is a type I transmembrane protein that acts as a receptor for ligands like tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and amyloid precursor protein (APP)-derived peptides. Due to its involvement in cell apoptosis, particularly in neural cells, TNFRSF21 has garnered interest for its potential therapeutic applications in neurodegenerative diseases such as Alzheimer’s disease. Additionally, its function in immune cell regulation places it as a candidate target in autoimmune diseases and certain cancers.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

1 mg


size 2

5 mg


observerd MW

Molecular Weight: Calculated MW: 17.6 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys420-Ser568 Tag: N-terminal His tag


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

TNFRSF21


dry ice

No


availability

Shipped within 1-2 months.


alias

Tumor necrosis factor receptor superfamily member 21,DR6,CD358,BM-018,Death receptor 6


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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Tested Applications

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reactivity

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Tested Applications

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reactivity

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status

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clonality

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