Family main features
SLAMF6 (Signaling Lymphocytic Activation Molecule Family Member 6) is a surface receptor protein primarily expressed on cells of the immune system, including T cells, B cells, natural killer (NK) cells, and dendritic cells. SLAMF6 is part of the SLAM family, which belongs to the immunoglobulin (Ig) superfamily. SLAM receptors are involved in the regulation of immune responses and play a role in cellular communication during immune activation, regulation, and self-tolerance. SLAMF6 functions as a self-ligand, meaning it binds to another SLAMF6 molecule on an adjacent cell to mediate its effects, thus promoting homophilic interactions that help coordinate immune cell interactions and responses.
SLAMF6 has a key role in modulating T cell and NK cell activation, helping maintain immune homeostasis and contributing to immune tolerance mechanisms. It achieves these functions by signaling through its intracellular tail, which contains motifs that interact with downstream signaling molecules, notably SAP (SLAM-associated protein). SAP is a critical adapter molecule that enables SLAMF6 to signal effectively in immune cells, primarily influencing pathways involved in cell activation, differentiation, and cytokine production.
SLAMF6 is a transmembrane glycoprotein comprising approximately 335 amino acids. The structural organization of SLAMF6 includes the following domains:
Extracellular Domain:
Transmembrane Domain:
Cytoplasmic (Intracellular) Domain:
SLAMF6 is classified within the SLAM family, which includes several closely related immune receptors (e.g., SLAMF1, SLAMF2, SLAMF3, SLAMF4, SLAMF5, and SLAMF7). This family is a subset of the broader immunoglobulin superfamily and is predominantly involved in immune cell interactions and signaling.
SLAMF6, like other SLAM family members, operates primarily through homophilic interactions, although variations in binding affinity and function exist across different SLAM receptors. There are no distinct subtypes or isoforms of SLAMF6 identified as functionally unique; however, alternative splicing may generate minor isoforms in some cells, although these are not well characterized.
Immune Cell Activation and Regulation:
Regulation of NK Cell Cytotoxicity:
Role in Immune Homeostasis and Tolerance:
Involvement in Autoimmune Diseases:
Autoimmune Disease:
Cancer Immunotherapy:
Genetic Disorders:
SLAMF6 is a receptor within the SLAM family that plays a pivotal role in regulating immune cell interactions, primarily among T cells and NK cells. The protein structure of SLAMF6 includes two extracellular Ig-like domains that mediate homophilic binding, a single transmembrane domain anchoring the receptor in the membrane, and an intracellular domain with critical ITSM motifs that interact with signaling molecules, especially SAP.
SLAMF6 signaling influences immune cell activation, survival, and cytokine production, with distinct roles in regulating NK cell cytotoxicity and T cell responses. Its function is modulated through interactions with adapter proteins like SAP, which facilitate both activating and inhibitory signals depending on cellular context. SLAMF6’s involvement in immune homeostasis and self-tolerance underscores its relevance in autoimmune disease, and its dysregulation is associated with conditions such as SLE.
In cancer, SLAMF6 represents a potential target for immunotherapy, as enhancing its signaling could augment the immune system’s ability to fight tumor cells. However, clinical application of SLAMF6-targeted therapies must balance potential benefits with the risk of immune-related side effects. Overall, SLAMF6 is a key immunoregulatory receptor with significant roles in both health and disease, making it an important subject of research in immunology and therapeutic development.
SLAM family member 6 (SLAMF6)
Activating NK receptor,KALI,NTBA,CD352,KALIb,Ly108,NTB-A,SF2000,NK-T-B-antigen
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits) relacionados con SLAMF6 - SLAM family member 6
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Esta página contiene 17 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | SLAMF6 | abx546077 | Human SLAM family member 6 (SLAMF6) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q96DU3 | RUO | ||
Abbexa | SLAMF6 | abx546078 | Mouse SLAM family member 6 (SLAMF6) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9ET39 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | SLAMF6 | abx337711 | SLAM Family Member 6 (SLAMF6) Antibody (Biotin) | Human | Polyclonal | Rabbit | SLAM Family Member 6 (SLAMF6) | Biotin | ELISA | 162.5 | 20 µg | Q96DU3 | RUO | |
Abbexa | SLAMF6 | abx337710 | SLAM Family Member 6 (SLAMF6) Antibody (FITC) | Human | Polyclonal | Rabbit | SLAM Family Member 6 (SLAMF6) | FITC | 162.5 | 20 µg | Q96DU3 | RUO | ||
Abbexa | SLAMF6 | abx337709 | SLAM Family Member 6 (SLAMF6) Antibody (HRP) | Human | Polyclonal | Rabbit | SLAM Family Member 6 (SLAMF6) | HRP | ELISA | 162.5 | 20 µg | Q96DU3 | RUO | |
Abbexa | SLAMF6 | abx028571 | SLAM Family Member 6 (SLAMF6) Antibody | Human | Polyclonal | Rabbit | SLAM Family Member 6 (SLAMF6) | Unconjugated | ELISA, WB | 281.25 | 80 µl | Q96DU3 | RUO | |
Abbexa | SLAMF6 | abx126554 | SLAM Family Member 6 (SLAMF6) Antibody | Human | Polyclonal | Rabbit | SLAM Family Member 6 (SLAMF6) | Unconjugated | WB | 175 | 20 µl | Q96DU3 | RUO | |
Abbexa | SLAMF6 | abx140637 | SLAM Family Member 6 (SLAMF6) Antibody | Human | Monoclonal | Mouse | SLAM Family Member 6 (SLAMF6) | Unconjugated | IF/ICC, FCM, IP | 287.5 | 0.1 mg | Q96DU3 | RUO | |
Abbexa | SLAMF6 | abx347177 | SLAM Family Member 6 (SLAMF6) Antibody (PE) | Human | Monoclonal | Mouse | SLAM Family Member 6 (SLAMF6) | PE | FCM | 400 | 100 tests | Q96DU3 | RUO | |
Abbexa | SLAMF6 | abx338635 | SLAM Family Member 6 (SLAMF6) Antibody | Human | Polyclonal | Rabbit | SLAM Family Member 6 (SLAMF6) | Unconjugated | ELISA, WB, IHC, IF/ICC | 162.5 | 20 µg | Q96DU3 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | SLAMF6 | abx260978 | SLAMF6 Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 5 µg | Q96DU3 | RUO | ||
Abbexa | SLAMF6 | abx691275 | Human SLAM Family Member 6 (SLAMF6) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 100 µg | Q96DU3-1 | RUO | |
Abbexa | SLAMF6 | abx694056 | Human SLAM Family Member 6 (SLAMF6) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 100 µg | Q96DU3-1 | RUO | |
Abbexa | SLAMF6 | abx692102 | Mouse SLAM Family Member 6 (SLAMF6) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 100 µg | Q9ET39 | RUO | |
Abbexa | SLAMF6 | abx680132 | Human SLAM family member 6 (SLAMF6) Protein | Human | Recombinant | Insect | Unconjugated | SDS-PAGE | 225 | 2 µg | RUO | |
Abbexa | SLAMF6 | abx692518 | Human SLAM Family Member 6 (SLAMF6) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 100 µg | Q96DU3-1 | RUO | |
Abbexa | SLAMF6 | abx691274 | Human SLAM Family Member 6 (SLAMF6) Protein | Human | Recombinant | Human | SDS-PAGE | 212.5 | 10 µg | Q96DU3 | RUO |
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