Human SLAM Family Member 6 (SLAMF6) Protein (Active)

Product specifications

Proteins and Peptides

Slam Family Member 6 (SLAMF6)

HEK293 cells

Activity: Active
Sequence Fragment: Met1-Met226
Tag: C-terminal His tag

Human

24.3 kDa

Recombinant

> 90% (SDS-PAGE)

100 µg

Lyophilized

SDS-PAGE

Prior to lyophilization: Sterile PBS, pH 7.4.

Shipped within 5-15 working days.

Storage: Store lyophilized between -20 °C and -80°C.
Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months.
Shelf Life: 12 months.

No

Q96DU3-1

Activating NK receptor,KALI,NTBA,CD352,KALIb,Ly108,NTB-A,SF2000,NK-T-B-antigen

Protein SLAMF6

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Endotoxin Level: < 1.0 EU per µg (LAL method).

Descripción

SLAMF6 (Signaling Lymphocytic Activation Molecule Family Member 6) is a surface receptor protein primarily expressed on cells of the immune system, including T cells, B cells, natural killer (NK) cells, and dendritic cells. SLAMF6 is part of the SLAM family, which belongs to the immunoglobulin (Ig) superfamily. SLAM receptors are involved in the regulation of immune responses and play a role in cellular communication during immune activation, regulation, and self-tolerance. SLAMF6 functions as a self-ligand, meaning it binds to another SLAMF6 molecule on an adjacent cell to mediate its effects, thus promoting homophilic interactions that help coordinate immune cell interactions and responses. SLAMF6 has a key role in modulating T cell and NK cell activation, helping maintain immune homeostasis and contributing to immune tolerance mechanisms. It achieves these functions by signaling through its intracellular tail, which contains motifs that interact with downstream signaling molecules, notably SAP (SLAM-associated protein). SAP is a critical adapter molecule that enables SLAMF6 to signal effectively in immune cells, primarily influencing pathways involved in cell activation, differentiation, and cytokine production.

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The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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