Human SLAM Family Member 6 (SLAMF6) Protein

Product specifications

Proteins and Peptides

SLAMF6

HEK293 cells

Human

Molecular Weight: 50.1 kDa
Sequence Fragment: Met1-Met226
Tag: C-terminal Fc tag
Validity: The validity for this protein is 12 months.

Recombinant

97.5+1.3% (SDS-PAGE)

100 µg

SDS-PAGE

Lyophilized from sterile PBS, pH 7.4.

Shipped within 5-15 working days.

Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.

No

Q96DU3-1

Activating NK receptor,KALI,NTBA,CD352,KALIb,Ly108,NTB-A,SF2000,NK-T-B-antigen

Protein SLAMF6

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

SLAMF6 (Signaling Lymphocytic Activation Molecule Family Member 6) is a surface receptor protein primarily expressed on cells of the immune system, including T cells, B cells, natural killer (NK) cells, and dendritic cells. SLAMF6 is part of the SLAM family, which belongs to the immunoglobulin (Ig) superfamily. SLAM receptors are involved in the regulation of immune responses and play a role in cellular communication during immune activation, regulation, and self-tolerance. SLAMF6 functions as a self-ligand, meaning it binds to another SLAMF6 molecule on an adjacent cell to mediate its effects, thus promoting homophilic interactions that help coordinate immune cell interactions and responses. SLAMF6 has a key role in modulating T cell and NK cell activation, helping maintain immune homeostasis and contributing to immune tolerance mechanisms. It achieves these functions by signaling through its intracellular tail, which contains motifs that interact with downstream signaling molecules, notably SAP (SLAM-associated protein). SAP is a critical adapter molecule that enables SLAMF6 to signal effectively in immune cells, primarily influencing pathways involved in cell activation, differentiation, and cytokine production.

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The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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