Human SLAM Family Member 6 (SLAMF6) Protein
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Description
Human SLAMF6 Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human SLAMF6 (Q96DU3-1)(Met1-Met226) was expressed with six amino acids (LEVLFQ) at the C-terminus.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | SLAMF6 |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: 23.9 kDa Sequence Fragment: Met1-Met226 Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96DU3-1 |
| Alias | Activating NK receptor,KALI,NTBA,CD352,KALIb,Ly108,NTB-A,SF2000,NK-T-B-antigen |
| Background | Protein SLAMF6 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
SLAMF6 (Signaling Lymphocytic Activation Molecule Family Member 6) is a surface receptor protein primarily expressed on cells of the immune system, including T cells, B cells, natural killer (NK) cells, and dendritic cells. SLAMF6 is part of the SLAM family, which belongs to the immunoglobulin (Ig) superfamily. SLAM receptors are involved in the regulation of immune responses and play a role in cellular communication during immune activation, regulation, and self-tolerance. SLAMF6 functions as a self-ligand, meaning it binds to another SLAMF6 molecule on an adjacent cell to mediate its effects, thus promoting homophilic interactions that help coordinate immune cell interactions and responses. SLAMF6 has a key role in modulating T cell and NK cell activation, helping maintain immune homeostasis and contributing to immune tolerance mechanisms. It achieves these functions by signaling through its intracellular tail, which contains motifs that interact with downstream signaling molecules, notably SAP (SLAM-associated protein). SAP is a critical adapter molecule that enables SLAMF6 to signal effectively in immune cells, primarily influencing pathways involved in cell activation, differentiation, and cytokine production.
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