Family main features
Bone Marrow Stromal Cell Antigen 2 (BST2), also known as tetherin, is a type II transmembrane protein that plays a significant role in the immune response. It is involved in antiviral defenses, specifically by restricting the release of enveloped viruses from infected cells. BST2 was first identified on bone marrow stromal cells, but it is now known to be expressed broadly across different cell types, especially in immune cells, including B cells, dendritic cells, and monocytes. Its antiviral function is key for innate immunity, as BST2 restricts viruses like HIV, Ebola, and others by physically tethering budding virions to the cell surface, preventing their release into the extracellular environment where they can infect new cells.
BST2 is also implicated in various physiological processes beyond viral restriction, including immune signaling, cell adhesion, and tumor development. Its expression is upregulated by interferons, a group of cytokines involved in immune signaling, which is indicative of its role in responding to infections and potentially other stressors within the body.
BST2 is a relatively small protein with unique structural features that are crucial for its function:
Transmembrane Domain:
Extracellular Coiled-Coil Domain:
GPI Anchor:
N-linked Glycosylation Sites:
BST2 is classified as a type II transmembrane protein and is part of the tetherin family, characterized by its antiviral tethering ability. Unlike many other antiviral proteins, BST2 is unique in its structural composition, enabling it to anchor both to the cell membrane and viral particles. While no isoforms or subtypes have been widely characterized for BST2, there is evidence that post-translational modifications, such as glycosylation and phosphorylation, can modulate its activity and interactions with other proteins.
BST2 is essential in the host’s innate immune response to viral infections and contributes to immune signaling:
Antiviral Activity:
Immune Activation and Signaling:
Role in Cancer:
Cell Adhesion:
BST2’s role in antiviral defense and cancer biology has drawn attention to its clinical relevance:
HIV and Viral Infections:
Cancer:
Autoimmune Diseases:
Interferonopathies:
BST2, or tetherin, is a multifunctional protein central to antiviral defense, immune signaling, and potentially cancer progression. Its unique structure, featuring a transmembrane domain, extracellular coiled-coil domain, and GPI anchor, enables it to “tether” viral particles to the cell surface, thereby restricting viral release and spread. In addition to its antiviral role, BST2 is involved in immune cell adhesion, NF-κB signaling, and response to interferons, making it a key player in both innate immunity and inflammation.
Clinically, BST2’s antiviral properties have important implications for managing HIV and other viral infections, especially as viruses have evolved mechanisms to inhibit its function. In cancer, BST2 may serve as a biomarker and therapeutic target due to its role in cell adhesion and immune modulation. BST2’s upregulation by interferons highlights its potential involvement in interferonopathies and autoimmune diseases, though further research is needed to fully understand these roles.
Overall, BST2 is a critical immune molecule with diverse functions across antiviral defense, immune regulation, and cellular adhesion, and its clinical relevance spans infectious diseases, oncology, and immunology. Understanding its structural and functional properties could pave the way for novel therapeutic interventions targeting BST2 in various diseases.
bone marrow stromal cell antigen 2 (BST2)
CD317,HM1.24,TETHERIN,HM1.24 antigen
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, CLIA Kits, ELISA Kits) relacionados con BST2 - bone marrow stromal cell antigen 2
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 17 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | BST2 | abx493068 | Human Bone Marrow Stromal Cell Antigen 2 (BST2) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.055 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | BST2 | abx150844 | Human Bone Marrow Stromal Cell Antigen 2 (BST2) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 662.5 | 96 tests | RUO | |
Abbexa | BST2 | abx388698 | Mouse Bone Marrow Stromal Antigen 2 (BST2) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 35 pg/ml | 687.5 | 96 tests | Q8R2Q8 | RUO |
Abbexa | BST2 | abx391030 | Rat Bone Marrow Stromal Antigen 2 (BST2) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 687.5 | 96 tests | Q811A2 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | BST2 | FNab00970 | anti- BST2 antibody | human | polyclonal | Rabbit | bone marrow stromal cell antigen 2 | IgG | Unconjugated | ELISA, WB, IHC, IF, FC | 100µg | Q10589 | RUO | |
Abbexa | BST2 | abx230970 | Bone Marrow Stromal Antigen 2 (BST2) Antibody | Human | Polyclonal | Rabbit | Bone Marrow Stromal Antigen 2 (BST2) | Unconjugated | ELISA, WB, IHC, IF/ICC, FCM | 350 | 100 µg | Q10589 | RUO | |
Abbexa | BST2 | abx119589 | Bone Marrow Stromal Antigen 2 (BST2) Antibody | Human | Polyclonal | Rabbit | Bone Marrow Stromal Antigen 2 (BST2) | Unconjugated | WB | 43.75 | 10 µg | Q10589 | RUO | |
Abbexa | BST2 | abx323331 | Bone Marrow Stromal Cell Antigen 2 (BST2) Antibody | Human | Polyclonal | Rabbit | Bone Marrow Stromal Cell Antigen 2 (BST2) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q10589 | RUO | |
Abbexa | BST2 | abx111238 | Bone Marrow Stromal Cell Antigen 2 (BST2) Antibody | Human | Polyclonal | Rabbit | Bone Marrow Stromal Cell Antigen 2 (BST2) | Unconjugated | ELISA, WB | 612.5 | 100 µl | Q10589 | RUO | |
Abbexa | BST2 | abx324035 | Bone Marrow Stromal Cell Antigen 2 (BST2) Antibody | Human | Polyclonal | Rabbit | Bone Marrow Stromal Cell Antigen 2 (BST2) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q10589 | RUO | |
Abbexa | BST2 | abx320195 | Bone Marrow Stromal Antigen 2 (BST2) Antibody | Human | Polyclonal | Rabbit | Bone Marrow Stromal Antigen 2 (BST2) | Unconjugated | ELISA, IHC | 237.5 | 50 µl | Q10589 | RUO | |
Abbexa | BST2 | abx001564 | Bone Marrow Stromal Antigen 2 (BST2) Antibody | Human | Polyclonal | Rabbit | Bone Marrow Stromal Antigen 2 (BST2) | Unconjugated | WB | 175 | 20 µl | Q10589 | RUO | |
Abbexa | BST2 | abx125580 | Bone Marrow Stromal Antigen 2 (BST2) Antibody | Human | Polyclonal | Rabbit | Bone Marrow Stromal Antigen 2 (BST2) | Unconjugated | WB, IHC, IF/ICC | 175 | 20 µl | Q10589 | RUO | |
Abbexa | BST2 | abx125579 | Bone Marrow Stromal Antigen 2 (BST2) Antibody | Human | Polyclonal | Rabbit | Bone Marrow Stromal Antigen 2 (BST2) | Unconjugated | WB, IHC | 175 | 20 µl | Q10589 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | BST2 | abx652673 | Human Bone Marrow Stromal Cell Antigen 2 (BST2) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | RUO | |
Abbexa | BST2 | abx262367 | Human Bone Marrow Stromal Antigen 2 (BST2) Protein | Human | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | Q10589 | RUO | |
Abbexa | BST2 | abx693071 | Mouse Bone Marrow Stromal Antigen 2 (BST2) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 50 µg | Q8R2Q8 | RUO |
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