Human Bone Marrow Stromal Cell Antigen 2 (BST2) Protein
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Description
Human Bone Marrow Stromal Cell Antigen 2 (BST2) Protein is a Recombinant Human protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Bone Marrow Stromal Cell Antigen 2 (BST2) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 16.3 kDa Observed MW: 18 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asn49-Ser161 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | CD317,HM1.24,TETHERIN,HM1.24 antigen |
| Background | Protein BST2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Bone Marrow Stromal Cell Antigen 2 (BST2), also known as tetherin, is a type II transmembrane protein that plays a significant role in the immune response. It is involved in antiviral defenses, specifically by restricting the release of enveloped viruses from infected cells. BST2 was first identified on bone marrow stromal cells, but it is now known to be expressed broadly across different cell types, especially in immune cells, including B cells, dendritic cells, and monocytes. Its antiviral function is key for innate immunity, as BST2 restricts viruses like HIV, Ebola, and others by physically tethering budding virions to the cell surface, preventing their release into the extracellular environment where they can infect new cells. BST2 is also implicated in various physiological processes beyond viral restriction, including immune signaling, cell adhesion, and tumor development. Its expression is upregulated by interferons, a group of cytokines involved in immune signaling, which is indicative of its role in responding to infections and potentially other stressors within the body.
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