Bone Marrow Stromal Antigen 2 (BST2) Antibody
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Description
BST2 Antibody is a Rabbit Polyclonal antibody against BST2. Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Bone Marrow Stromal Antigen 2 (BST2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q10589 |
| Gene ID | 684 |
| NCBI Accession | NP_004326.1 |
| Alias | CD317,HM1.24,TETHERIN,HM1.24 antigen |
| Background | Antibody anti-BST2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Bone Marrow Stromal Cell Antigen 2 (BST2), also known as tetherin, is a type II transmembrane protein that plays a significant role in the immune response. It is involved in antiviral defenses, specifically by restricting the release of enveloped viruses from infected cells. BST2 was first identified on bone marrow stromal cells, but it is now known to be expressed broadly across different cell types, especially in immune cells, including B cells, dendritic cells, and monocytes. Its antiviral function is key for innate immunity, as BST2 restricts viruses like HIV, Ebola, and others by physically tethering budding virions to the cell surface, preventing their release into the extracellular environment where they can infect new cells. BST2 is also implicated in various physiological processes beyond viral restriction, including immune signaling, cell adhesion, and tumor development. Its expression is upregulated by interferons, a group of cytokines involved in immune signaling, which is indicative of its role in responding to infections and potentially other stressors within the body.
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IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1(HIV-1), human immunodeficiency virus type 2(HIV-2), simian immunodeficiency viruses(SIVs), equine infectious anemia virus(EIAV), feline immunodeficiency virus(FIV), prototype foamy virus(PFV), Mason-Pfizer monkey virus(MPMV), human T-cell leukemia virus type 1(HTLV-1), Rous sarcoma virus(RSV) and murine leukemia virus(MLV), flavivirideae: hepatitis C virus(HCV), filoviridae: ebola virus(EBOV) and marburg virus(MARV), arenaviridae: lassa virus(LASV) and machupo virus(MACV), herpesviridae: kaposis sarcoma-associated herpesvirus(KSHV), rhabdoviridae: vesicular stomatitis virus(VSV), orthomyxoviridae: influenza A virus, and paramyxoviridae: nipah virus. Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Isoform 1 and isoform 2 are both effective viral restriction factors but have differing antiviral and signaling activities. Isoform 2 is resistant to HIV-1 Vpu-mediated degradation and restricts HIV-1 viral budding in the presence of Vpu. Isoform 1 acts as an activator of NF-kappa-B and this activity is inhibited by isoform 2.
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Bone Marrow Stromal Antigen 2 (BST2) Antibody
BST2 Antibody is a Rabbit Polyclonal antibody against BST2. Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis.
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