Bone Marrow Stromal Cell Antigen 2 (BST2) Antibody
221€ (50 µg)
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Name
Bone Marrow Stromal Cell Antigen 2 (BST2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx324035
Tested Applications
ELISA, WB
Description
BST2 Antibody is a Rabbit Polyclonal against BST2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Bone Marrow Stromal Cell Antigen 2 (BST2) Immunogen: Synthesized peptide derived from the Internal region of human BST-2. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/5000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q10589 |
| Gene ID | 684 |
| Alias | CD317,HM1.24,TETHERIN,HM1.24 antigen |
| Background | Antibody anti-BST2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Bone Marrow Stromal Cell Antigen 2 (BST2), also known as tetherin, is a type II transmembrane protein that plays a significant role in the immune response. It is involved in antiviral defenses, specifically by restricting the release of enveloped viruses from infected cells. BST2 was first identified on bone marrow stromal cells, but it is now known to be expressed broadly across different cell types, especially in immune cells, including B cells, dendritic cells, and monocytes. Its antiviral function is key for innate immunity, as BST2 restricts viruses like HIV, Ebola, and others by physically tethering budding virions to the cell surface, preventing their release into the extracellular environment where they can infect new cells. BST2 is also implicated in various physiological processes beyond viral restriction, including immune signaling, cell adhesion, and tumor development. Its expression is upregulated by interferons, a group of cytokines involved in immune signaling, which is indicative of its role in responding to infections and potentially other stressors within the body.
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