Family main features
CASP8 and FADD-like apoptosis regulator (CFLAR), also known as c-FLIP (cellular FLICE-like inhibitory protein), is a critical regulator of apoptosis and necroptosis, acting predominantly as an inhibitor of caspase-8. CFLAR is essential for controlling the balance between cell survival and programmed cell death, which is crucial for maintaining tissue homeostasis and immune responses. Apoptosis is a highly regulated process of programmed cell death essential for development, immune function, and the elimination of damaged or diseased cells. CFLAR was identified due to its homology with caspase-8 (FLICE) and its ability to interact with FADD (Fas-Associated protein with Death Domain), a key adaptor protein in death receptor signaling pathways.
CFLAR exists in multiple isoforms, with c-FLIPL (long form) and c-FLIPS (short form) being the most studied. These isoforms are generated through alternative splicing and have distinct regulatory roles in apoptotic signaling. By modulating the activity of caspase-8, CFLAR prevents the induction of apoptosis via death receptors such as Fas, TNFR1, and TRAIL receptors, thereby influencing immune responses and cell fate decisions.
CFLAR’s structure is integral to its function as an apoptosis regulator:
CFLAR is primarily classified based on its isoforms:
CFLAR is essential for several cellular processes:
Dysregulation of CFLAR is implicated in several diseases:
CFLAR (c-FLIP) is a crucial regulator of apoptosis and necroptosis, primarily functioning as an inhibitor of caspase-8. The protein contains two DEDs and, in the long isoform (c-FLIPL), a caspase-like domain without catalytic activity. CFLAR prevents apoptosis by inhibiting caspase-8 activation at the DISC, thereby playing a significant role in cell survival and immune regulation. Its dysregulation is associated with various pathological conditions, including cancer, autoimmune diseases, and cardiovascular disorders. Understanding the precise mechanisms by which CFLAR controls cell death and survival pathways continues to be a critical area of research, offering potential therapeutic targets for a range of diseases.
CASP8 and FADD-like apoptosis regulator
CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASP8 and FADD like apoptosis regulator, cFLIP
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits, CLIA Kits) relacionados con CFLAR - CASP8 and FADD-like apoptosis regulator
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Esta página contiene 34 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | CFLAR | EH1762 | Human CFLAR(CASP8 and FADD-like apoptosis regulator) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 78.125-5000pg/ml | 96T | O15519 | RUO | ||
Abbexa | CFLAR | abx258174 | Human CASP8 And FADD Like Apoptosis Regulator (CFLAR) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | CFLAR | abx495915 | Human CASP8 And FADD Like Apoptosis Regulator (CFLAR) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.058 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | CFLAR | abx555890 | Mouse CASP8 And FADD Like Apoptosis Regulator (CFLAR) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | 687.5 | 96 tests | O35732 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
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FineTest | CFLAR | FNab01621 | anti- CFLAR/FLIP antibody | human | polyclonal | Rabbit | CASP8 and FADD-like apoptosis regulator | IgG | Unconjugated | ELISA, WB, IHC, IF, IP | 100µg | RUO | ||
Abbexa | CFLAR | abx034233 | CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody | Human | Polyclonal | Rabbit | CASP8 And FADD Like Apoptosis Regulator (CFLAR) | Unconjugated | ELISA, WB, IHC, FCM | 281.25 | 80 µl | O15519 | RUO | |
Abbexa | CFLAR | abx303393 | CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody (Biotin) | Human | Polyclonal | Rabbit | CASP8 And FADD Like Apoptosis Regulator (CFLAR) | Biotin | ELISA | 162.5 | 20 µg | O15519 | RUO | |
Abbexa | CFLAR | abx015815 | CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody | Human | Monoclonal | Mouse | CASP8 And FADD Like Apoptosis Regulator (CFLAR) | Unconjugated | ELISA, IHC | 362.5 | 100 µl | O15519 | RUO | |
Abbexa | CFLAR | abx303392 | CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody (FITC) | Human | Polyclonal | Rabbit | CASP8 And FADD Like Apoptosis Regulator (CFLAR) | FITC | 162.5 | 20 µg | O15519 | RUO | ||
Abbexa | CFLAR | abx137446 | CASP8 And FADD-Like Apoptosis Regulator (CFLAR) Antibody | Human | Monoclonal | Mouse | CASP8 And FADD-Like Apoptosis Regulator (CFLAR) | Unconjugated | 225 | 5 µg | RUO | |||
Abbexa | CFLAR | abx231621 | CFLAR / FLIP Antibody | Human | Polyclonal | Rabbit | CFLAR/FLIP | Unconjugated | ELISA, WB, IHC, IF/ICC, IP | 350 | 100 µg | RUO | ||
Abbexa | CFLAR | abx324522 | CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody | Human | Polyclonal | Rabbit | CASP8 And FADD Like Apoptosis Regulator (CFLAR) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | O15519 | RUO | |
Abbexa | CFLAR | abx370682 | CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody Pair | Human | CASP8 And FADD Like Apoptosis Regulator (CFLAR) | ELISA | 1600 | 5 × 96 tests | RUO | |||||
Abbexa | CFLAR | abx339604 | CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody | Human | Polyclonal | Rabbit | CASP8 And FADD Like Apoptosis Regulator (CFLAR) | Unconjugated | ELISA, WB | 250 | 50 µl | O15519 | RUO | |
Abbexa | CFLAR | abx339657 | CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody | Human | Polyclonal | Rabbit | CASP8 And FADD Like Apoptosis Regulator (CFLAR) | Unconjugated | ELISA, WB | 250 | 50 µl | O15519 | RUO | |
Abbexa | CFLAR | abx340041 | CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody | Human | Polyclonal | Rabbit | CASP8 And FADD Like Apoptosis Regulator (CFLAR) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | CFLAR | abx303391 | CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody (HRP) | Human | Polyclonal | Rabbit | CASP8 And FADD Like Apoptosis Regulator (CFLAR) | HRP | ELISA | 162.5 | 20 µg | O15519 | RUO | |
Abbexa | CFLAR | abx302699 | CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody | Human | Polyclonal | Rabbit | CASP8 And FADD Like Apoptosis Regulator (CFLAR) | Unconjugated | ELISA, WB, IHC, IF/ICC | 162.5 | 20 µg | O15519 | RUO | |
Abbexa | CFLAR | abx323810 | CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody | Human | Polyclonal | Rabbit | CASP8 And FADD Like Apoptosis Regulator (CFLAR) | Unconjugated | ELISA, WB | 187.5 | 50 µg | O15519 | RUO | |
Abbexa | CFLAR | abx339441 | CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody | Human | Polyclonal | Rabbit | CASP8 And FADD Like Apoptosis Regulator (CFLAR) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | O15519 | RUO | |
Abbexa | CFLAR | abx412444 | FLICE-Like Inhibitory Protein Long Form (CFLAR) Antibody | Human | Polyclonal | Rabbit | FLICE-Like Inhibitory Protein Long Form (CFLAR) | Unconjugated | WB, IHC | 537.5 | 100 µg | O15519 | RUO | |
Abbexa | CFLAR | abx212054 | CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody | Human | Polyclonal | Rabbit | CASP8 And FADD Like Apoptosis Regulator (CFLAR) | Unconjugated | ELISA, WB | 250 | 50 µl | O15519 | RUO | |
Abbexa | CFLAR | abx211827 | CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody | Human | Polyclonal | Rabbit | CASP8 And FADD Like Apoptosis Regulator (CFLAR) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | O15519 | RUO | |
Abbexa | CFLAR | abx213232 | CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody | Human | Polyclonal | Rabbit | CASP8 And FADD Like Apoptosis Regulator (CFLAR) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | O15519 | RUO | |
Abbexa | CFLAR | abx211601 | CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody | Human | Polyclonal | Rabbit | CASP8 And FADD Like Apoptosis Regulator (CFLAR) | Unconjugated | ELISA, IHC | 250 | 50 µl | O15519 | RUO | |
Abbexa | CFLAR | abx015816 | CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody | Human | Monoclonal | Mouse | CASP8 And FADD Like Apoptosis Regulator (CFLAR) | Unconjugated | ELISA, WB, IHC, FCM | 362.5 | 100 µl | RUO | ||
Abbexa | CFLAR | abx211826 | CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody | Human | Polyclonal | Rabbit | CASP8 And FADD Like Apoptosis Regulator (CFLAR) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | O15519 | RUO | |
Abbexa | CFLAR | abx001992 | CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody | Human | Polyclonal | Rabbit | CASP8 And FADD Like Apoptosis Regulator (CFLAR) | Unconjugated | WB | 175 | 20 µl | O15519 | RUO | |
Abbexa | CFLAR | abx412461 | FLICE-Like Inhibitory Protein Long Form (CFLAR) Antibody | Mouse | Polyclonal | Rabbit | FLICE-Like Inhibitory Protein Long Form (CFLAR) | Unconjugated | WB, IF/ICC | 537.5 | 100 µg | O35732 | RUO | |
Abbexa | CFLAR | abx104103 | CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody | Mouse | Polyclonal | Rabbit | CASP8 And FADD Like Apoptosis Regulator (CFLAR) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | O35732 | RUO | |
Abbexa | CFLAR | abx130374 | CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody | Rat | Polyclonal | Rabbit | CASP8 And FADD Like Apoptosis Regulator (CFLAR) | Unconjugated | WB, IHC, IF/ICC | 300 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CFLAR | abx261489 | CASP8 and FADD-Like Apoptosis Regulator Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 5 µg | O15519 | RUO | ||
Abbexa | CFLAR | abx065746 | Mouse CASP8 And FADD Like Apoptosis Regulator (CFLAR) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | O35732 | RUO |
Abbexa | CFLAR | abx168536 | Rat CASP8 And FADD Like Apoptosis Regulator (CFLAR) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | RUO |
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