CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody
Pida mas información
935106861
info@markelab.com
Precio
383.5€ (100 µl)
Antibody anti-CFLAR
proveedor
Abbexareference
abx015816Tested Applications
ELISA, WB, IHC, FCMreactivity
Human, Mousestatus
RUOclonality
MonoclonalDescripción
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8.However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8.Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists.
Background
CASP8 and FADD-like apoptosis regulator (CFLAR), also known as c-FLIP, is an important regulatory protein that modulates apoptosis, particularly in response to death receptor signaling. CFLAR is structurally related to the caspase family but lacks protease activity, allowing it to inhibit caspase-8 activation in the death receptor pathway. By binding to the death-inducing signaling complex (DISC), CFLAR blocks the activation of downstream apoptotic signaling, effectively acting as an inhibitor of apoptosis. This inhibition allows cells to evade cell death, and as such, CFLAR has been implicated in promoting cell survival in various cancers, as well as playing a role in immune responses.
Características del producto
category
Primary Antibodies
clonality
Monoclonal
reactivity
Human, Mouse
immunogen target
CASP8 And FADD Like Apoptosis Regulator (CFLAR)
host
Mouse
isotype
IgG1
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC, FCM
purification
Purified from ascites by Protein G chromatography.
recommended dilution
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, containing 0.05% sodium azide.
size 1
100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
CFLAR
dry ice
No
availability
Shipped within 5-10 working days.
alias
CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASP8 and FADD like apoptosis regulator, cFLIP
note
Concentration: 1 mg/ml -
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