CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody (HRP)
169€ (20 µg)
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935106861
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name
CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody (HRP)
category
Primary Antibodies
provider
Abbexa
reference
abx303391
tested applications
ELISA
Description
CFLAR Antibody (HRP) is a Rabbit Polyclonal against CFLAR conjugated to HRP.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | CASP8 And FADD Like Apoptosis Regulator (CFLAR) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15519 |
| Gene ID | 8837 |
| NCBI Accession | NP_001120655.1, NM_001127183.2 |
| OMIM | 603599 |
| Alias | CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASP8 and FADD like apoptosis regulator, cFLIP |
| Background | Antibody anti-CFLAR |
| Status | RUO |
Descripción
CASP8 and FADD-like apoptosis regulator (CFLAR), also known as c-FLIP, is an important regulatory protein that modulates apoptosis, particularly in response to death receptor signaling. CFLAR is structurally related to the caspase family but lacks protease activity, allowing it to inhibit caspase-8 activation in the death receptor pathway. By binding to the death-inducing signaling complex (DISC), CFLAR blocks the activation of downstream apoptotic signaling, effectively acting as an inhibitor of apoptosis. This inhibition allows cells to evade cell death, and as such, CFLAR has been implicated in promoting cell survival in various cancers, as well as playing a role in immune responses.
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